EEF1D modulates proliferation and epithelial-mesenchymal transition in oral squamous cell carcinoma
ARTIGO
Inglês
EEF1D (eukaryotic translation elongation factor 1δ) is a subunit of the elongation factor 1 complex of proteins that mediates the elongation process during protein synthesis via enzymatic delivery of aminoacyl-tRNAs to the ribosome. Although the functions of EEF1D in the translation process are...
EEF1D (eukaryotic translation elongation factor 1δ) is a subunit of the elongation factor 1 complex of proteins that mediates the elongation process during protein synthesis via enzymatic delivery of aminoacyl-tRNAs to the ribosome. Although the functions of EEF1D in the translation process are recognized, EEF1D expression was found to be unbalanced in tumours. In the present study, we demonstrate the overexpression of EEF1D in OSCC (oral squamous cell carcinoma), and revealed that EEF1D and protein interaction partners promote the activation of cyclin D1 and vimentin proteins. EEF1D knockdown in OSCC reduced cell proliferation and induced EMT (epithelial-mesenchymal transition) phenotypes, including cell invasion. Taken together, these results define EEF1D as a critical inducer of OSCC proliferation and EMT
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
2009/54067-3; 2010/19278-0; 2011/22421- 2; 2009/53839-2; 2013/01607-6
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
470567/2009-0; 470549/2011-4; 301702/2011-0; 470268/2013-1
fechado
DOI: https://doi.org/10.1042/CS20150646
Texto completo: http://www.clinsci.org/content/130/10/785.long
EEF1D modulates proliferation and epithelial-mesenchymal transition in oral squamous cell carcinoma
EEF1D modulates proliferation and epithelial-mesenchymal transition in oral squamous cell carcinoma
Fontes
Clinical science: an international journal of translational science and medicine Vol. 130, no. 10 (May, 2016), p. 785-799 |