Fatty acid synthase inhibition with orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model

Fatty acid synthase inhibition with orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model

Marco A. Carvalho, Karina G. Zecchin, Fabiana Seguin, Débora C. Bastos, Michelle Agostini, Ana Lúcia C. A. Rangel, Sílvio S. Veiga, Helena F. Raposo, Helena C. F. Oliveira, Massimo Loda, Ricardo D. Coletta, Edgard Graner

ARTIGO

Inglês

Fatty acid synthase (FASN) is the enzyme responsible for the endogenous synthesis of the saturated fatty acid palmitate. In contrast to most normal cells, malignant cells depend on FASN activity for growth and survival. In fact, FASN is overexpressed in a variety of human cancers including cutaneous...

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ

fechado

Fatty acid synthase inhibition with orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model

Marco A. Carvalho, Karina G. Zecchin, Fabiana Seguin, Débora C. Bastos, Michelle Agostini, Ana Lúcia C. A. Rangel, Sílvio S. Veiga, Helena F. Raposo, Helena C. F. Oliveira, Massimo Loda, Ricardo D. Coletta, Edgard Graner


										

Fatty acid synthase inhibition with orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model

Marco A. Carvalho, Karina G. Zecchin, Fabiana Seguin, Débora C. Bastos, Michelle Agostini, Ana Lúcia C. A. Rangel, Sílvio S. Veiga, Helena F. Raposo, Helena C. F. Oliveira, Massimo Loda, Ricardo D. Coletta, Edgard Graner

    Fontes

    International journal of cancer

    Vol. 123, no. 11 (Dec., 2008), p. 2557-2565