This study aimed to evaluate the effect of various silane-containing solutions on bonding between resin cement and glass ceramic after 24 hours and after six months of water storage. Glass-ceramic plaques ( IPS e.max CAD) were sandblasted with aluminum oxide, etched with 10% hydrofluoric acid (HF), and divided into five "silane treatment'' groups: RelyX Ceramic Primer (RCP), RelyX Ceramic Primer and Single Bond Plus (RCP+SB), Scotchbond Universal (SBU), Clearfil Ceramic Primer (CP), and no solution (HF-only control). Each group was divided into two "storage time'' subgroups: 24 hours or six months in 37 degrees C water. Eighteen resin cement cylinders (RelyX Ultimate) were bonded to each treatment group substrate (n=18) and then subjected to microshear testing. Failure mode was analyzed using scanning electron microscopy. Debond data were analyzed using a two-way analysis of variance and the Tukey post hoc test (alpha=0.05) as well as Weibull distributions. The factors "silane treatment,'' "storage time,'' (p < 0.0001), and their interaction were statistically significant (p < 0.0010). Group means (MPa +/- SD), RCP (24 hours: 27.2 +/- 3.1; six months: 18.0 +/- 4.9), and HF-only control (24 hours: 21.1 +/- 3.4; six months: 15.7 +/- 5.8) showed a reduced bond strength after six months of water storage, while RCP + SB (24 hours: 23.4 +/- 4.4; six months: 22.2 +/- 5.4), SBU (24 hours: 18.8 +/- 3.0; six months: 17.2 +/- 3.6), and CP (24 hours: 21.7 +/- 4.3; six months: 17.4 +/- 4.8) remained constant. Weibull analysis revealed that more reliable bond strengths were obtained after six months for SBU and RCP + SB. Evaluation by scanning electron microscopy revealed that all groups demonstrated hydrolytic degradation at six months of storage, but RCP + SB and SBU indicated less. Use of a separate application of silane and adhesive system improved short and long-term ceramic/resin cement bond strength Ver menos