Nasopharyngeal angiofibroma is a benign but aggressive tumor of unknown etiology, typically occur_x0002_ring in adolescent males. It is described as a rare neoplasm; however, the prevalence seems to have geographic differ_x0002_ences. All cases referred to our head and neck clinical and pathology...

Nasopharyngeal angiofibroma is a benign but aggressive tumor of unknown etiology, typically occur_x0002_ring in adolescent males. It is described as a rare neoplasm; however, the prevalence seems to have geographic differ_x0002_ences. All cases referred to our head and neck clinical and pathology service were reviewed. Most of the patients pre_x0002_sented at an advanced stage. The clinical and radiographic features are presented and discussed. Histologically, the tumor shows a highly vascular fibrous proliferation with characteristic plump, angulated and stellate cells, catego_x0002_rized as fibroblasts. Immunohistochemistry was performed on 42 cases to further elucidate the nature of these cells. The stromal cells expressed vimentin and factor XIIIa, the latter expressed most commonly in the giant stellate cells. Inflammation was almost exclusively present in periph_x0002_eral subepithelial areas. Mast cells were abundant, even in the absence of other inflammatory cells. Lymphatics were observed principally in peripheral regions. Proliferating cells (Ki-67 reactive) were restricted to endothelial cells

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