Bilateral multiple oncocytic cysts of the parotid gland in type 2 diabetes patients
Ciro D Soares, Roman Carlos, Marcelo V B Mota, Maria G F de Carvalho, Thayná M de Lima Morais, Oslei P de Almeida, Albina Altemani
ARTIGO
Inglês
Agradecimentos: Supported by FAPESP grant 2015/25905-1
Abstract: The hallmarks of type 2 diabetes (T2D) are hyperglycaemia and insulin resistance. These factors, at the cellular level, are associated with mitochondrial dysfunction and increased glucose uptake. Such events are poorly explored in the context of the salivary glands. In this study, we...
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Abstract: The hallmarks of type 2 diabetes (T2D) are hyperglycaemia and insulin resistance. These factors, at the cellular level, are associated with mitochondrial dysfunction and increased glucose uptake. Such events are poorly explored in the context of the salivary glands. In this study, we present a series of eight cases of a distinct salivary gland lesion characterised by multiple oncocytic cysts, and we provide new pathological insights regarding its pathogenesis. Seven patients (87.5%) had confirmed T2D, and obesity was identified in five (62.5%) patients. Clinically, the patients showed bilateral parotid gland swelling with recurrent episodes of pain and enlargement. Imaging examination revealed multiple cystic lesions in both parotid glands. Microscopically, the parotid glands showed multiple cysts of different sizes, lined by oncocytic epithelial cells. Intraluminally, strongly eosinophilic glass-like crystalloid material was observed. Immunohistochemical studies were performed, and the most notable finding was glucose transporter 1 (GLUT1) overexpression in the oncocytic cysts which is not observed in any other oncocytic lesion of patients without T2D. In addition, high expressions of mitochondrial antigen, fission 1 protein and mitofusin-2 were observed in the oncocytic epithelium of the cysts. Furthermore, most of the oncocytic cysts showed a pattern of cytokeratin expression consistent with striated ducts.These results strongly suggest that T2D is associated with alterations in GLUT1 expression in the cells of striated ducts with mitochondrial dysfunction, causing a hyperplastic process characterised by multiple oncocytic cysts. For this lesion, the designation of ‘diabetes-associated–bilateral multiple oncocytic cysts of the parotid gland’ is proposed
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FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
2015/25905-1
Fechado
Bilateral multiple oncocytic cysts of the parotid gland in type 2 diabetes patients
Ciro D Soares, Roman Carlos, Marcelo V B Mota, Maria G F de Carvalho, Thayná M de Lima Morais, Oslei P de Almeida, Albina Altemani
Bilateral multiple oncocytic cysts of the parotid gland in type 2 diabetes patients
Ciro D Soares, Roman Carlos, Marcelo V B Mota, Maria G F de Carvalho, Thayná M de Lima Morais, Oslei P de Almeida, Albina Altemani
Fontes
Histopathology (Fonte avulsa) |