Inhibition of matrix metalloproteinase-9 activity by doxycycline ameliorates RANK ligand-induced osteoclast differentiation in vitro and in vivo

Inhibition of matrix metalloproteinase-9 activity by doxycycline ameliorates RANK ligand-induced osteoclast differentiation in vitro and in vivo

G. C. N. Franco, M. Kajiya, T. Nakanishi, K. Ohta, P. L. Rosalen, F. C. Groppo, C. W. O. Ernst, J. L. Boyesen, J. D. Bartlett, P. Stashenko, M. A. Taubman, T. Kawai

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Inglês

Tetracycline antibiotics, including doxycycli\e (DOX), have been used to treat bone resorptive diseases, partially because of their activity to suppress osteoclastogenesis induced by receptor activator of nuclear factor kappa B ligand (RANKL). However, their precise inhibitory mechanism remains...

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Inhibition of matrix metalloproteinase-9 activity by doxycycline ameliorates RANK ligand-induced osteoclast differentiation in vitro and in vivo

G. C. N. Franco, M. Kajiya, T. Nakanishi, K. Ohta, P. L. Rosalen, F. C. Groppo, C. W. O. Ernst, J. L. Boyesen, J. D. Bartlett, P. Stashenko, M. A. Taubman, T. Kawai


										

Inhibition of matrix metalloproteinase-9 activity by doxycycline ameliorates RANK ligand-induced osteoclast differentiation in vitro and in vivo

G. C. N. Franco, M. Kajiya, T. Nakanishi, K. Ohta, P. L. Rosalen, F. C. Groppo, C. W. O. Ernst, J. L. Boyesen, J. D. Bartlett, P. Stashenko, M. A. Taubman, T. Kawai

    Fontes

    Experimental cell research

    Vol. 317, no. 10 (June, 2011), p. 1454-1464