Agradecimentos: This study was supported by the São Paulo State Research Foundation (FAPESP), Brazil (grant numbers 2016/07269-3, 2016/11470-6 and 2017/18916-2), and in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance code 001. The authors express...

Agradecimentos: This study was supported by the São Paulo State Research Foundation (FAPESP), Brazil (grant numbers 2016/07269-3, 2016/11470-6 and 2017/18916-2), and in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance code 001. The authors express their gratitude to the Brazilian Nanotechnology National Laboratory (LNNano) for the use of XRD, AFM, and XPS facilities and to the Microscopy Laboratory of Araraquara School of Dentistry (UNESP) for the use of Confocal Fluorescence Microscopy facilities. Additionally, this work made use of the EPIC facility of Northwestern University’s NUANCE Center, which has received support from the Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205); the MRSEC program (NSF DMR-1720139) at the Materials Research Center; the International Institute for Nanotechnology (IIN); the Keck Foundation; and the State of Illinois, through the IIN

In this study, β-tantalum oxide (β-Ta2O5) thin film was synthesized via magnetron sputtering to improve the surface properties, cytocompatibility and electrochemical stability of titanium. X-ray diffraction analysis confirmed a crystalline orthorhombic phase of Ta2O5 film on the β-Ta2O5 experimental...

In this study, β-tantalum oxide (β-Ta2O5) thin film was synthesized via magnetron sputtering to improve the surface properties, cytocompatibility and electrochemical stability of titanium. X-ray diffraction analysis confirmed a crystalline orthorhombic phase of Ta2O5 film on the β-Ta2O5 experimental surface. A granular structure with a complex and hierarchical nature was demonstrated by atomic force microscopy. Ta2O5-treated surfaces exhibited greater roughness and hydrophilicity compared with untreated titanium discs (control). Enhanced electrochemical stability in simulated body fluid (pH 7.4) was noted for Ta2O5-treated surfaces wherein higher values of charge transfer resistance, nobler corrosion potential, and lower capacitance, corrosion current density, and corrosion rate values were observed vs untreated control. Real-time monitoring of albumin and fibrinogen proteins adsorption by an electrochemical quartz crystal microbalance disclosed similar protein interactions for control and Ta2O5-treated discs, with higher fibrinogen adsorption rates for Ta2O5-treated surfaces. Cell culture assays (MC3T3-E1 cells) demonstrated that Ta2O5-treated discs featured greater in vitro mineral nodule formation, normal cell morphology and spreading, and increased mRNA levels of runt-related transcription factor 2 (Runx-2), osteocalcin (Ocn), and collagen-1 (Col-1). Therefore, it can be concluded that β-Ta2O5 thin films may be considered a promising strategy to trigger superior long-term stability and biological properties of titanium implants

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

2016/07269-3; 2016/11470-6; 2017/18916-2

COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES

001

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