This study comprises a systematic review of studies evaluating the effect ofvarious well-recognized regenerative techniques for the managementof furcation lesions in specific clinical scenarios compared with non-regenerative surgical therapy. The following clinical scenarios were evalu-ated: (1)...

This study comprises a systematic review of studies evaluating the effect ofvarious well-recognized regenerative techniques for the managementof furcation lesions in specific clinical scenarios compared with non-regenerative surgical therapy. The following clinical scenarios were evalu-ated: (1) maxillary molars with facial/interproximal Class I furcationdefects; (2) mandibular molars with facial/lingual Class I furcation defects;(3) maxillary molars with facial/interproximal Class II furcation defects;(4) mandibular molars with facial/lingual Class II furcation defects; (5)maxillary molars with Class III furcation defects; (6) mandibular molarswith Class III furcation defects; and (7) maxillary premolars with Class I,II, or III furcation defects. Two investigators reviewed four databases (MEDLINE/PubMed, Scopus, Web of Knowledge, and the Cochrane CentralRegister of Controlled Trials) for human studies published in English,matching specific inclusion criteria (see below inKey Study Factorsection).Initially 1500 entries were identified. The total number of articles selectedafter reviewing the titles and abstracts was 183, of which 150 were eligibleafter full-text review. A total of 24 clinical trials and 13 case series did notreport clearly the clinical scenarios for the furcation defects. A total of113 manuscripts were included in the systematic review (6 systematicreviews, 85 clinical trials, 14 case series, and 8 case reports)

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