Decreased CD1a(+), CD83(+) and factor XIIIa(+) dendritic cells in cervical lymph nodes and palatine tonsils of AIDS patients
R. Gondak, L. P. Kowalski, F. Soares, L. Schultz, T. Mauad, P. A. Vargas
ARTIGO
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The purpose of this study was to quantify and compare the density of dendritic cells (DCs) in cervical lymph nodes (LNs) and palatine tonsils (PTs) of AIDS and non-AIDS patients. Factor XIIIa, CD1a and CD83 antibodies were used to identify migratory DCs by immunohistochemistry in LNs and PTs of 32...
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The purpose of this study was to quantify and compare the density of dendritic cells (DCs) in cervical lymph nodes (LNs) and palatine tonsils (PTs) of AIDS and non-AIDS patients. Factor XIIIa, CD1a and CD83 antibodies were used to identify migratory DCs by immunohistochemistry in LNs and PTs of 32 AIDS patients and 21 HIV-negative control patients. Quantification was performed by the positive pixel count analytical method. AIDS patients presented a lower density of factor XIIIa(+) cells (P<0.001), CD1a(+) cells (P<0.05) and CD83(+) cells (P<0.001) in cervical LNs and PTs compared to the non-AIDS control group. Overall depletion of DCs in lymphoid tissues of AIDS patients may be predictive of the immune system's loss of disease control
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FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
10/51956-9
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
302011/2010-2
Fechado
Decreased CD1a(+), CD83(+) and factor XIIIa(+) dendritic cells in cervical lymph nodes and palatine tonsils of AIDS patients
R. Gondak, L. P. Kowalski, F. Soares, L. Schultz, T. Mauad, P. A. Vargas
Decreased CD1a(+), CD83(+) and factor XIIIa(+) dendritic cells in cervical lymph nodes and palatine tonsils of AIDS patients
R. Gondak, L. P. Kowalski, F. Soares, L. Schultz, T. Mauad, P. A. Vargas
Fontes
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Histopathology Vol. 64, no. 2 (Jan., 2014), p. 234-241 |