Occlusal trauma (OT) and smoking are both factors that alter alveolar bone metabolism and therefore could synergistically act on alveolar bone loss. The aim of this experimental study was to evaluate the influence of short-term cigarette smoke inhalation (CSI) on inter-radicular alveolar bone loss...

Occlusal trauma (OT) and smoking are both factors that alter alveolar bone metabolism and therefore could synergistically act on alveolar bone loss. The aim of this experimental study was to evaluate the influence of short-term cigarette smoke inhalation (CSI) on inter-radicular alveolar bone loss promoted by primary OT in a rat model. Forty-eight animals were randomly assigned to one of three groups based on treatment type: OT+CSI (n=16), animals were exposed to CSI three times per day, for 8min per exposure, and they concomitantly received unilateral vertical augmentation creating an occlusal interference inducing experimental OT; OT (n=16), animals received only unilateral vertical augmentation; negative control (NC; n=16), animals maintained for equal periods to achieve periodontal baseline values of periodontal ligament dimension. Each group was divided into two subgroups (n=8) based on treatment length: 7 or 14d. After 7d, the OT+CSI group exhibited significantly higher bone loss compared to the NC group (p=0.0022). After 14d, the OT (p<0.0001) and OT+CSI (p<0.0001) groups presented significantly higher bone loss compared to the NC group, and OT+CSI resulted in significantly higher bone loss than OT alone (p=0.0241). The number of tartrate-resistant acid phosphatase-positive cells on the linear surface of the bone crest after 7d was significantly higher in the OT+CSI group as compared to the NC and OT groups (p<0.0001 and p=0.0045, respectively) and remained significantly higher in the OT+CSI group after 14d, compared to the OT group (p<0.0001). Short-term CSI increases early bone loss in association with OT after 7d, and this worsens in severity after 14d of exposure

COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES

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