Inhibition of fatty acid synthase in melanoma cells activates the intrinsic pathway of apoptosis

Inhibition of fatty acid synthase in melanoma cells activates the intrinsic pathway of apoptosis

K.G. Zecchin, F.A. Rossato, H.F. Raposo, D.R. Melo, L.C. Alberici, H.C. Oliveira, R.F. Castilho, R.D. Coletta, A.E. Vercesi, E. Graner

ARTIGO

Inglês

Fatty acid synthase (FASN) is the metabolic enzyme responsible for the endogenous synthesis of the saturated long-chain fatty acid, palmitate. In contrast to most normal cells, FASN is overexpressed in a variety of human cancers, including cutaneous melanoma, in which its levels of expression are...

CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES

Fechado

Inhibition of fatty acid synthase in melanoma cells activates the intrinsic pathway of apoptosis

K.G. Zecchin, F.A. Rossato, H.F. Raposo, D.R. Melo, L.C. Alberici, H.C. Oliveira, R.F. Castilho, R.D. Coletta, A.E. Vercesi, E. Graner


										

Inhibition of fatty acid synthase in melanoma cells activates the intrinsic pathway of apoptosis

K.G. Zecchin, F.A. Rossato, H.F. Raposo, D.R. Melo, L.C. Alberici, H.C. Oliveira, R.F. Castilho, R.D. Coletta, A.E. Vercesi, E. Graner

    Fontes

    Laboratory investigation

    Vol. 91, no. 2 (Feb., 2011), p. 232-240