Identification of a bioactive compound isolated from brazilian propolis type 6
M.L. Castro, A.M. Nascimento, M. Ikegaki, C.M. Costa-Neto, S.M. Alencar, P.L. Rosalen
ARTIGO
Inglês
A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilian propolis type 6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC50 = 0.1756 μM), strong antimicrobial activity (MIC...
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A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilian propolis type 6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC50 = 0.1756 μM), strong antimicrobial activity (MIC range-0.73-6.6 μg/mL; MBC range-2.92-106 μg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good.
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FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAIS - FAPEMIG
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
131758/2006-3; 302222/2008-1
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
2004/08635-6
Fechado
Identification of a bioactive compound isolated from brazilian propolis type 6
M.L. Castro, A.M. Nascimento, M. Ikegaki, C.M. Costa-Neto, S.M. Alencar, P.L. Rosalen
Identification of a bioactive compound isolated from brazilian propolis type 6
M.L. Castro, A.M. Nascimento, M. Ikegaki, C.M. Costa-Neto, S.M. Alencar, P.L. Rosalen
Fontes
Bioorganic and medicinal chemistry (Fonte avulsa) |