Pharmacokinetic and local toxicity studies of liposome-encapsulated and plain mepivacaine solutions in rats
G. R. Tofoli, C. M. S. Cereda, D. R. de Araujo, E. de Paula, R. B. Brito, J. Pedrazzoli, E. Meurer, F. A. P. Barros, F. C. Groppo, M. C. Volpato, J. Ranali
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The pharmacokinetics and the local toxicity of commercial and liposome-encapsulated mepivacaine formulations injected intra-orally in rats were studied. Animals were divided in groups (n=4-6) and treated with 0.1 mL of the formulations: 2% mepivacaine with 1:100,000 epinephrine (MVC(2%EPI)), 3%...
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The pharmacokinetics and the local toxicity of commercial and liposome-encapsulated mepivacaine formulations injected intra-orally in rats were studied. Animals were divided in groups (n=4-6) and treated with 0.1 mL of the formulations: 2% mepivacaine with 1:100,000 epinephrine (MVC(2%EPI)), 3% mepivacaine (MVC(3%)), and 2% liposome-encapsulated mepivacaine (MVC(LUV)). The results showed that the 2% liposome-encapsulated mepivacaine reduced C(max), prolonged AUC(0-infinity) and t(1/2) compared with 3% plain and 2% vasoconstritor-associated mepivacaine, after intraoral injection. In addition, it was also observed that liposomal mepivacaine might protect the tissue against local inflammation evoked by plain or vasoconstrictors-associated mepivacaine, giving supporting evidence for its safety and possible clinical use in dentistry
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CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
2006/00121-9
aberto
Pharmacokinetic and local toxicity studies of liposome-encapsulated and plain mepivacaine solutions in rats
G. R. Tofoli, C. M. S. Cereda, D. R. de Araujo, E. de Paula, R. B. Brito, J. Pedrazzoli, E. Meurer, F. A. P. Barros, F. C. Groppo, M. C. Volpato, J. Ranali
Pharmacokinetic and local toxicity studies of liposome-encapsulated and plain mepivacaine solutions in rats
G. R. Tofoli, C. M. S. Cereda, D. R. de Araujo, E. de Paula, R. B. Brito, J. Pedrazzoli, E. Meurer, F. A. P. Barros, F. C. Groppo, M. C. Volpato, J. Ranali
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