Pharmacokinetic and local toxicity studies of liposome-encapsulated and plain mepivacaine solutions in rats

Pharmacokinetic and local toxicity studies of liposome-encapsulated and plain mepivacaine solutions in rats

G. R. Tofoli, C. M. S. Cereda, D. R. de Araujo, E. de Paula, R. B. Brito, J. Pedrazzoli, E. Meurer, F. A. P. Barros, F. C. Groppo, M. C. Volpato, J. Ranali

ARTIGO

Inglês

The pharmacokinetics and the local toxicity of commercial and liposome-encapsulated mepivacaine formulations injected intra-orally in rats were studied. Animals were divided in groups (n=4-6) and treated with 0.1 mL of the formulations: 2% mepivacaine with 1:100,000 epinephrine (MVC(2%EPI)), 3%...

CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

aberto

Pharmacokinetic and local toxicity studies of liposome-encapsulated and plain mepivacaine solutions in rats

G. R. Tofoli, C. M. S. Cereda, D. R. de Araujo, E. de Paula, R. B. Brito, J. Pedrazzoli, E. Meurer, F. A. P. Barros, F. C. Groppo, M. C. Volpato, J. Ranali


										

Pharmacokinetic and local toxicity studies of liposome-encapsulated and plain mepivacaine solutions in rats

G. R. Tofoli, C. M. S. Cereda, D. R. de Araujo, E. de Paula, R. B. Brito, J. Pedrazzoli, E. Meurer, F. A. P. Barros, F. C. Groppo, M. C. Volpato, J. Ranali

    Fontes

    Drug delivery

    Vol. 17, no. 2 (Feb., 2010), p. 68-76