Poly (L-lactic acid) (PLLA) is a biocompatible polymer widely used in a range of applications and is already recognized in the medical field as a biomaterial. The main objective of the present work
was the production of polymeric mats to be applied in tissue engineering. PLLA mats were produced...

Poly (L-lactic acid) (PLLA) is a biocompatible polymer widely used in a range of applications and is already recognized in the medical field as a biomaterial. The main objective of the present work
was the production of polymeric mats to be applied in tissue engineering. PLLA mats were produced through the centrifugal spinning process. Scanning electron microscopy (SEM) analyzed the fibers diameter, disposition, and morphology. The fibers presented a uniform and constant diameter (16.24 µm), being arranged randomly. Thermogravimetric analysis (TGA) technique verified variation of
mass loss with temperature, in which the material degradation temperature started at 205 °C. Differential scanning calorimetry (DSC) determined phase transition temperatures. Fourier-transform infrared spectroscopy (FT-IR) evaluated PLLA fibrous membrane chemical groups. Cytotoxicity assays verified fibroblasts and osteoblasts viabilities by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide), AlamarBlue®, and Live/Dead® for 24, 48, and 72 h. This work results demonstrated that PLLA mats have great potential for tissue engineering applications in wound healing
and bone repairing, being a promising biomaterial with high biocompatibility

COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

2008/57680-3

Fechado