Development of mucoadhesive sericin/alginate particles loaded with ibuprofen for sustained drug delivery
Emanuelle D. Freitas, Jacyara M. M. Vidart, Edson A. Silva, Meuris G. C. da Silva, Melissa G. A. Vieira
ARTIGO
Inglês
A sericin/alginate blend was successfully applied as a matrix for incorporation of ibuprofen. This provided a sustained release formulation, which could improve the therapeutic efficacy of ibuprofen and patient adherence to treatment. Sericin increased the proportion of drug incorporated into the...
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A sericin/alginate blend was successfully applied as a matrix for incorporation of ibuprofen. This provided a sustained release formulation, which could improve the therapeutic efficacy of ibuprofen and patient adherence to treatment. Sericin increased the proportion of drug incorporated into the particles (i.e., the drug incorporation efficiency), with incorporation rates between 73.01% +/- 1.70% and 94.15% +/- 4.21%. Alginate affected the drug release, and the particles with the maximum alginate mass fraction tested (2.8%) showed sustained release through a dissolution mechanism, reaching equilibrium after about 1400 min. Analysis of the incorporation efficiency and the drug release time showed the best results were for formulations with a high alginate content. Scanning electron microscopy, Fourier transform infrared spectroscopy, and X-ray diffraction analysis were used for particle characterization to study the incorporation of ibuprofen. The particle size range was 0.80 +/- 0.13 to 1.08 +/- 0.11 mm. The size distributions of sericin-containing particles showed a good fit with the Gaussian model
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CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
470615/2013-3; 300986/2013-0
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
2015/13505-9; 2016/05007-1
Fechado
Development of mucoadhesive sericin/alginate particles loaded with ibuprofen for sustained drug delivery
Emanuelle D. Freitas, Jacyara M. M. Vidart, Edson A. Silva, Meuris G. C. da Silva, Melissa G. A. Vieira
Development of mucoadhesive sericin/alginate particles loaded with ibuprofen for sustained drug delivery
Emanuelle D. Freitas, Jacyara M. M. Vidart, Edson A. Silva, Meuris G. C. da Silva, Melissa G. A. Vieira
Fontes
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Particuology Vol. 41 (Dec., 2018), p. 65-73 |