Agradecimentos: The authors are also thankful to Fundação para a Ciência e Tecnologia do Ministério da Ciência e Tecnologia, under the reference PTDC/SAU-FAR/113100/2009

This study focuses on the physicochemical characterization of lipid materials useful for the production of the so-called solid lipid nanoparticles (SLN) and nano-structured lipid carriers (NLC). The chosen lipids were Dynasan (R) 114 (glyceril trimyristate) and Dynasan (R) 118 (glyceril tristearate)...

This study focuses on the physicochemical characterization of lipid materials useful for the production of the so-called solid lipid nanoparticles (SLN) and nano-structured lipid carriers (NLC). The chosen lipids were Dynasan (R) 114 (glyceril trimyristate) and Dynasan (R) 118 (glyceril tristearate) as solid lipids (SL), melting temperature above 80 degrees C, and Miglyol (R) 812 (caprylic/capric triglyceride) and Miglyol (R) 840 (propylene glycol dicaprylate/dicaprate) as liquid lipids (LL), crystallizing below -15 degrees C. Raw lipids (pure or SL: LL mixtures) were analyzed by differential scanning calorimetry (DSC), wide angle X-ray diffraction (WAXD), and Polarized Light Microscopy (PLM), before and after tempering at 80 degrees C for 1 h. The selected SL:LL combination was 70% (Dynasan (R) 114 and 118) and 30% (Miglyol (R) 812 and 840) for the production of SLN and NLC by high-pressure homogenization (HPH), respectively. Particles with a mean size of 200 nm (poly-dispersity index <0.329) and zeta potential of -15 mV were obtained, and their long-term stability was confirmed for 3 months of storage at 7 degrees C

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES

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