In the current work, a coating system consisted of a laser-structured surface, a thin layer primer and a polymeric coating to improve degradation behaviour of biocompatible and biodegradable Mg alloy is presented. The laser structuring allowed modification of surface topography as well as controlling the wettability of surface. The cellulose acetate primer provided protection from in-process degradation of samples during the successive layer-by-layer (LbL) coating process, where alternate layers of chitosan and carboxymethyl cellulose were applied. The results revealed that the laser structured surface plays an important role on the developed coating structure and final corrosion rate. Lowest corrosion rate among the coated samples (1.15 cm yr−1) was measured for the most hydrophilic laser-treated surface, corresponding to almost 16% reduction compared to the as-received samples Ver menos