Influence of polyethylene glycol-8-lauryl ester in the structural lipid of the elastic liposomes
Raquel de Melo Barbosa, Christine Lamenha Luna Finkler, Patrícia Severino, Maria Helena Andrade Santana
ARTIGO
Inglês
This study compared the physicochemical characteristics of conventional and elastic liposomes in terms of surfactant incorporation, flow rate, elasticity, mean diameter, phospholipid content and permeation capability. Surfactants were incorporated into conventional liposomes in order to enhance the...
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This study compared the physicochemical characteristics of conventional and elastic liposomes in terms of surfactant incorporation, flow rate, elasticity, mean diameter, phospholipid content and permeation capability. Surfactants were incorporated into conventional liposomes in order to enhance the transdermal transport of drugs through the stratum corneum. The unilamellar liposomes produced composed of egg phosphatidylcholine (PCegg) as the structural component and polyethylene glycol-8-lauryl ester (PEG8L) as the elastic component. Results showed fluidity increased of the lipid bilayer with surfactant incorporation, and particle integrity was preserved. These factors determined the ability of elastic liposomes to permeate nanoporous membranes. The elastic liposomes presented a size of ~100 nm and a polydispersity index of 0.38. The flow rate of the liposomes through membranes obeyed Darcy's law, with characteristics similar to those of water. The findings demonstrate the potential of elastic liposomes for transdermal drug administration
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CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
150044/2004-6
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
02/12637-9
Fechado
Influence of polyethylene glycol-8-lauryl ester in the structural lipid of the elastic liposomes
Raquel de Melo Barbosa, Christine Lamenha Luna Finkler, Patrícia Severino, Maria Helena Andrade Santana
Influence of polyethylene glycol-8-lauryl ester in the structural lipid of the elastic liposomes
Raquel de Melo Barbosa, Christine Lamenha Luna Finkler, Patrícia Severino, Maria Helena Andrade Santana
Fontes
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African journal of pharmacy and pharmacology Vol. 8, no. 38 (Oct., 2014), p. 969-977 |