Effects of diffusion and mixing pattern on microfluidic-assisted synthesis of chitosan/ATP nanoparticles
Amanda C. S. N. Pessoa, Caroline C. Sipoli, Lucimara G. de la Torre
ARTIGO
Inglês
Chitosan (CHI) nanoparticles present promising applications in pharmaceutical and biomedical fields, including drug and gene delivery. Among different approaches, microfluidics emerges as a resourceful tool for nanoparticle production in low-cost, reproducible processes with predictable fluid...
Chitosan (CHI) nanoparticles present promising applications in pharmaceutical and biomedical fields, including drug and gene delivery. Among different approaches, microfluidics emerges as a resourceful tool for nanoparticle production in low-cost, reproducible processes with predictable fluid dynamics. However, microfluidic-assisted synthesis of CHI nanoparticles has not been widely explored in the literature. In this context, we systematically investigated different process parameters that influence the synthesis of CHI/ATP nanoparticles. We highlight the effects and limitations of diffusion and distinct mixing patterns developed through the microchannels on the final physicochemical characteristics of CHI/ATP nanoparticles produced. To address these hurdles, here we describe a simple, feasible, and reproducible method for the production of CHI/ATP nanoparticles. This strategy enables the development of a continuous and homogeneous production process for CHI nanoparticles to be applied in the most varied fields of research
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
Fechado
Effects of diffusion and mixing pattern on microfluidic-assisted synthesis of chitosan/ATP nanoparticles
Amanda C. S. N. Pessoa, Caroline C. Sipoli, Lucimara G. de la Torre
Effects of diffusion and mixing pattern on microfluidic-assisted synthesis of chitosan/ATP nanoparticles
Amanda C. S. N. Pessoa, Caroline C. Sipoli, Lucimara G. de la Torre
Fontes
Lab on a chip Vol. 17 (2017), p. 2281-2293 |