Sorbitol-plasticized and neutralized chitosan membranes as skin substitutes
Maria Gabriela Nogueira Campos, Lucia Helena Innocentini Mei, Arnaldo Rodrigues Santos Jr
ARTIGO
Inglês
Chitosan is soluble in diluted acid solutions and can easily form films by casting. However, residual acid neutralization should be performed for biomedical applications what may compromise physical and mechanical properties of the films. Thus, plasticizers can be added to improve these properties....
Ver mais
Chitosan is soluble in diluted acid solutions and can easily form films by casting. However, residual acid neutralization should be performed for biomedical applications what may compromise physical and mechanical properties of the films. Thus, plasticizers can be added to improve these properties. The aim of this study was to characterize morphological, barrier and mechanical properties, besides evaluate the in vitro cytotoxicity of sorbitol-plasticized and NaOH-Na2CO3 neutralized chitosan membranes for skin substitute application. Scanning electron microscopy, X-ray diffraction, water vapor permeability and mechanical tests were carried out to characterize the obtained membranes. Moreover, Vero cells were used for in vitro cytotoxicity evaluation. In this paper, we report a non-cytotoxic sorbitol-plasticized chitosan membrane with desirable properties for skin substitution, such as flexibility, water vapor permeability and high percentage of elongation
Ver menos
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES
Aberto
Sorbitol-plasticized and neutralized chitosan membranes as skin substitutes
Maria Gabriela Nogueira Campos, Lucia Helena Innocentini Mei, Arnaldo Rodrigues Santos Jr
Sorbitol-plasticized and neutralized chitosan membranes as skin substitutes
Maria Gabriela Nogueira Campos, Lucia Helena Innocentini Mei, Arnaldo Rodrigues Santos Jr
Fontes
Materials research. Ibero-american journal of materials (Fonte avulsa) |