A novel Triclosan Methacrylate-based composite reduces the virulence of Streptococcus mutans biofilm
Isaac Jordão de Souza Araújo, Andréia Bolzan de Paula, Roberta Caroline Bruschi Alonso, Jesus Roberto Taparelli, Lúcia Helena Innocentini Mei, Rafael Nóbrega Stipp, Regina Maria Puppin-Rontani
ARTIGO
Inglês
The use of antimicrobial monomers, linked to the polymer chain of resin composites, is an interesting approach to circumvent the effects of bacteria on the dental and material surfaces. In addition, it can likely reduce the incidence of recurrent caries lesions. The aim of this study was to evaluate...
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The use of antimicrobial monomers, linked to the polymer chain of resin composites, is an interesting approach to circumvent the effects of bacteria on the dental and material surfaces. In addition, it can likely reduce the incidence of recurrent caries lesions. The aim of this study was to evaluate the effects of a novel Triclosan Methacrylate (TM) monomer, which was developed and incorporated into an experimental resin composite, on Streptococcus mutans (S. mutans) biofilms, focusing on the analyses of vicR, gtfD, gtfC, covR, and gbpB gene expression, cell viability and biofilm characteristics. The contact time between TM-composite and S. mutans down-regulated the gbpB and covR and up-regulated the gtfC gene expression, reduced cell viability and significantly decreased parameters of the structure and characteristics of S. mutans biofilm virulence. The presence of Triclosan Methacrylate monomer causes harmful effects at molecular and cellular levels in S. mutans, implying a reduction in the virulence of those microorganisms
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FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
2012/10750-4
COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES
Aberto
A novel Triclosan Methacrylate-based composite reduces the virulence of Streptococcus mutans biofilm
Isaac Jordão de Souza Araújo, Andréia Bolzan de Paula, Roberta Caroline Bruschi Alonso, Jesus Roberto Taparelli, Lúcia Helena Innocentini Mei, Rafael Nóbrega Stipp, Regina Maria Puppin-Rontani
A novel Triclosan Methacrylate-based composite reduces the virulence of Streptococcus mutans biofilm
Isaac Jordão de Souza Araújo, Andréia Bolzan de Paula, Roberta Caroline Bruschi Alonso, Jesus Roberto Taparelli, Lúcia Helena Innocentini Mei, Rafael Nóbrega Stipp, Regina Maria Puppin-Rontani
Fontes
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PLoS one (2018) |