Refrigeration systems are major consumers of electrical energy in many process industries. Hydrocarbons have regained interest as refrigerants because of the increasing restrictions applied to halogenated fluids. In this work, the use of hydrocarbons mixed refrigerants and an alternative flash tank with vapor injection (FTVI) refrigeration cycle were combined. Five different binary mixed refrigerants involving R170 (ethane), R290 (propane), R600 (n-butane) and R600a (isobutane) were studied. Using different refrigerant compositions, the cycle was simulated and optimized for maximum COP, considering a fixed refrigeration capacity in the evaporator to reduce the temperature of a secondary thermal fluid from 281.55 K to 269.15 K. Parameters analyzed were: coefficient of performance, temperature glide in the evaporator and refrigerant mass flow rate. The use of a FTVI led to a COP improvement from 4% to 36% when compared to the traditional vapor compression cycle (VCC). The pair R290/R600 with 60/40 wt% presented the maximum COP of 4.88 Ver menos