Performance of the main downstream operations on hyaluronic acid purification
André Delano Domingos Cavalcanti, Bruna Alice Gomes de Melo, Bruno Armenio Moreira Ferreira, Maria Helena Andrade Santana
ARTIGO
Inglês
Hyaluronic acid (HA), or hyaluronan, is a natural polyelectrolyte, ubiquitous in human tissues. Exogenous HA has been a valuable material due to its wide range of medical applications, such as in osteoarthritis treatment, ophthalmic surgery, adhesion prevention after surgeries and wound healing, as...
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Hyaluronic acid (HA), or hyaluronan, is a natural polyelectrolyte, ubiquitous in human tissues. Exogenous HA has been a valuable material due to its wide range of medical applications, such as in osteoarthritis treatment, ophthalmic surgery, adhesion prevention after surgeries and wound healing, as well as cosmetic applications. However, to ensure the physicochemical and biological properties, a purity near to 99 % is a primary requirement, aiming clinical applications. To achieve this goal, various downstream operations have been used, aiming HA concentration, separation and purification. Precipitation with organic solvents has been a common operation in most purification processes, combined with other downstream operations such as precipitation with quaternary salts, filtration, adsorption and ion exchange. This work presents an updated review of HA purification, emphasizing the performance of the main downstream operations used to achieve highly purified HA, in the period from 1970 to 2019. We conclude that, in the majority of the published works, there is a lack of studies regarding the operational conditions, as well as an absence of the purification percentage development during the processes
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FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
2015/23134-8
COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
142480/2014-2
Fechado
Performance of the main downstream operations on hyaluronic acid purification
André Delano Domingos Cavalcanti, Bruna Alice Gomes de Melo, Bruno Armenio Moreira Ferreira, Maria Helena Andrade Santana
Performance of the main downstream operations on hyaluronic acid purification
André Delano Domingos Cavalcanti, Bruna Alice Gomes de Melo, Bruno Armenio Moreira Ferreira, Maria Helena Andrade Santana
Fontes
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Process biochemistry Vol. 99 (Dec., 2020), p. 160-170 |