Background: Wound evaluation and treatment is a field of knowledge in which nursing has a major role, and the application of a clinical simulation is important for promoting the educational process. Method: This study was a randomized clinical trial with randomization of nursing students into control and experimental groups, which were analysed before and after application of the teaching strategies. Results: The data obtained showed better performance of the experimental group in the Objective Structured Clinical Examination. Conclusion: Clinical simulation is effective in developing clinical reasoning in wound evaluation and treatment but has no significant effect on knowledge acquisition. (C) 2019 International Nursing Association for Clinical Simulation and Learning. Published by Elsevier Inc. All rights reserved Ver menos