This study investigated the adhesion and biofilm formation (S. aureus and C. Albicans) behavior on titanium dioxide (TiO2) nanotubes coating produce by anodization process on novel Ti-30Ta alloy to the dental implant application. The Ti-30Ta alloy was fabricated by mixing Ti cp and Tantalum using an...

This study investigated the adhesion and biofilm formation (S. aureus and C. Albicans) behavior on titanium dioxide (TiO2) nanotubes coating produce by anodization process on novel Ti-30Ta alloy to the dental implant application. The Ti-30Ta alloy was fabricated by mixing Ti cp and Tantalum using an arc-melting furnace in a high purity argon atmosphere. The resulting ingots were homogenized and then cold worked by swaging process. Discs with 6mm in diameter and 3mm in thickness were cutting. The anodization process was realized in an electrolyte solution containing 0.2 M NH4F at 30 V for 6 h. The nanotube layer was annealed in an oxygen ambient furnace at 530 ◦C (5◦ C/min) for 1 h. C. albicans and S. aureus were selected to investigate the antimicrobial activity. The number of colonyforming units per milliliter (CFU/mL) was determined and analyzed statistically (ANOVA, Tukey test, p < 0.05). Characterization techniques such as scanning electron microscopy (SEM) were used in order to investigate the surface of samples. The results demonstrate the influence of titanium dioxide nanotubes (TiO2) formation on bacterial adhesion and biofilm formation. Significant statistical differences (p < 0.05) for bacterial adhesion and biofilm formation were observed on surface covered with TiO2 nanotubes on novel Ti-30Ta alloy. SEM images show Ti-30Ta alloy with and without nanotubes after the biofilms have been grown by incubated at 37 ◦C for 48 h. The surface coating with nanotube decrease bacterial adhesion and biofilm formation. The TiO2 nanotube has an influence on bacterial adhesion and biofilm formation. The number of colony-forming units per millimeter has been decreasing after the anodization process. Thus, TiO2 nanotubes coating novel Ti-30Ta alloy can be promising in the dental implant field due to potential to prevent implant infection

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