Characterization and in vitro evaluation of electrospun aligned-fiber membranes of poly(L-co-D,L-lactic acid)
Claudenete Vieira Leal, Rosemeire dos Santos Almeida, Jose Luis Davila, Juliana Almeida Domingues, Moema A. Hausen, Eliana A. Rezende Duek, Marcos Akira d'Avila
ARTIGO
Inglês
Agradecimentos: This work was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq-Brazil, grant numbers N°401297/2014-4, N°308660/2015-3, and N°421745-2016-9). The authors are grateful to PPG BMA-UFSCAR Sorocaba by making available the use of the LSCM
poly(L-co-D,L-lactic acid) (PLDLA) is a bioresorbable and biocompatible copolymer obtained from the combination of L-lactic and D, L-lactic monomers. PLDLA membranes formed by aligned fibers were prepared by AC/DC electrospinning. Solutions of 8 and 10 wt % of PLDLA were used and membranes were...
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poly(L-co-D,L-lactic acid) (PLDLA) is a bioresorbable and biocompatible copolymer obtained from the combination of L-lactic and D, L-lactic monomers. PLDLA membranes formed by aligned fibers were prepared by AC/DC electrospinning. Solutions of 8 and 10 wt % of PLDLA were used and membranes were collected by a rotating cylindrical collector. The results showed a slight increase in the fiber diameter with the increase in the polymer concentration. Fourier transform infrared spectroscopy results showed no changes in the chemical structure. Dynamic mechanical analysis results showed an increase in the storage modulus and a decrease in glass-transition temperature for the 10 wt % samples, which was corroborated by differential scanning calorimetry. Thermogravimetric analysis showed a slight variation of the peak degradation temperature. Nevertheless, the samples did not present solvent residues. The membranes were tested in vitro using adipose-derived mesenchymal stem cells (ASCs). The ASCs proliferated after 1, 7, and 14 days of culture, maintaining a spindle-like morphology, which evidences their potential for tissue engineering applications
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CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
401297/2014‐4; 421745‐2016‐9; 401297/2014‐4; 421745‐2016‐9
Fechado
Characterization and in vitro evaluation of electrospun aligned-fiber membranes of poly(L-co-D,L-lactic acid)
Claudenete Vieira Leal, Rosemeire dos Santos Almeida, Jose Luis Davila, Juliana Almeida Domingues, Moema A. Hausen, Eliana A. Rezende Duek, Marcos Akira d'Avila
Characterization and in vitro evaluation of electrospun aligned-fiber membranes of poly(L-co-D,L-lactic acid)
Claudenete Vieira Leal, Rosemeire dos Santos Almeida, Jose Luis Davila, Juliana Almeida Domingues, Moema A. Hausen, Eliana A. Rezende Duek, Marcos Akira d'Avila
Fontes
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Journal of applied polymer science Vol. 136, no. 24 (June, 2019), n. art. 47657 |