The successful use of polymer-enhanced oil recovery observed in the last two decades is leading to effective field implementations. One of the reasons for such positive results in polymer flooding is the integration between laboratory-measured properties and reservoir simulation. Recent reports show that inaccessible pore volume (IAPV) plays a significant role in the apparent viscosity of random coil polymers, such as hydrolyzed polyacrylamide (HPAM). This paper assesses both direct and indirect impacts of IAPV on polymer flooding. This investigation relies on laboratory and field-scale simulations of polymer flooding using CMG-STARS. Simulation cases review the effects of IAPV on production indicators in direct and indirect forms. This study compares laboratory-scale simulations with experimental results and uses quality indicators to evaluate the history matching of both approaches. It relies on a modified benchmark field case to study both approaches in comparison to waterflooding and idealized polymer flooding. Results indicate that IAPV has a small direct impact on production curves. However, data show significant indirect implications of the IAPV on recovery. This effect occurs because the apparent viscosity of HPAM has a direct relationship with IAPV. Although the simulation results were consistent with current literature, the results obtained through the experiments indicate that the most realistic simulation case is achieved when considering the impact of IAPV on polymer viscosity Ver menos