Specific matrix metalloproteinase 9 (MMP-9) haplotype affect the circulating MMP-9 levels in women with migraine
Alisson Martins-Oliveira, Flavia M. Gonçalves, Jose G. Speciali, Vanessa Fontana, Tatiane C. Izidoro-Toledo, Vanessa A. Belo, Fabiola Dach, Jose E. Tanus-Santos
ARTIGO
Inglês
We investigated whether three relevant polymorphisms (C-1562T, microsatellite − 90(CA)14–24, and Q279R) in the MMP-9 gene, or MMP-9 haplotypes, are associated with migraine and affect MMP-9 and tissue inhibitor of MMPs (TIMP)-1 levels in patients with migraine. We studied 102 healthy women...
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We investigated whether three relevant polymorphisms (C-1562T, microsatellite − 90(CA)14–24, and Q279R) in the MMP-9 gene, or MMP-9 haplotypes, are associated with migraine and affect MMP-9 and tissue inhibitor of MMPs (TIMP)-1 levels in patients with migraine. We studied 102 healthy women (controls) and 187 women with migraine (141 without aura — MWA, and 46 with aura — MA). Patients with MWA had higher plasma MMP-9 concentrations than patients with MA. Patients with MA had the highest TIMP-1 and lowest MMP-9/TIMP-1 ratios. The MMP-9 “C L Q” haplotype was associated with higher plasma MMP-9 concentrations in migraine patients
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FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
Fechado
Specific matrix metalloproteinase 9 (MMP-9) haplotype affect the circulating MMP-9 levels in women with migraine
Alisson Martins-Oliveira, Flavia M. Gonçalves, Jose G. Speciali, Vanessa Fontana, Tatiane C. Izidoro-Toledo, Vanessa A. Belo, Fabiola Dach, Jose E. Tanus-Santos
Specific matrix metalloproteinase 9 (MMP-9) haplotype affect the circulating MMP-9 levels in women with migraine
Alisson Martins-Oliveira, Flavia M. Gonçalves, Jose G. Speciali, Vanessa Fontana, Tatiane C. Izidoro-Toledo, Vanessa A. Belo, Fabiola Dach, Jose E. Tanus-Santos
Fontes
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Journal of neuroimmunology Vol. 252, no. 1-2 (Nov., 2012), p. 89-94 |