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Type: Artigo de periódico
Title: Spectrofluorimetry and chemometrics for investigation of norfloxacin distribution in multilamellar liposomes
Author: Zalloum, NL
Biloti, DN
Pessine, FBT
Abstract: Norfloxacin (NFX), a fluoroquinolone, was encapsulated in multi-lamellar liposomes (MLV) of soy-bean phosphatidylcholine at pH 7.0. The observed affinity of this class of drugs for hydrophobic environments, such as phospholipid bilayers, could lead to a better understanding of the mechanism of uptake in bacteria. The fluorescent properties of NFX were examined both free in solution and in MLV, using anisotropy and fluorescence quenching measurements. The latter data was treated with a chemometric method to deconvolute the overlapped spectra of zwitterionic and neutral species of NFX in equilibrium at this pH. The results show that NFX incorporates into the lipidic bilayers with two different distributions of species: the zwitterionic form in the lipid/aqueous interface, and the neutral one, more towards the center of the bilayer.
Subject: norfloxacin
Country: EUA
Editor: Soc Applied Spectroscopy
Citation: Applied Spectroscopy. Soc Applied Spectroscopy, v. 59, n. 8, n. 1032, n. 1036, 2005.
Rights: aberto
Identifier DOI: 10.1366/0003702054615179
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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