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Type: Artigo de periódico
Title: Long-Term Administration of BAY 41-2272 Prevents Bladder Dysfunction in Nitric Oxide-Deficient Rats
Author: Monica, FZ
Reges, R
Cohen, D
Silva, FH
De Nucci, G
D'Ancona, CAL
Antunes, E
Abstract: Aims: Chronic blockade of nitric oxide (NO) synthesis leads to detrusor smooth muscle overactivity. This study aimed to evaluate the protective effects of BAY 41-2272, a soluble guanlylate cyclase activator, on changes in cystometric parameters in NO-deficient rats. Methods: Rats were divided into the following groups: (a) control, (b) DMSO, (c) No-nitro-L-arginine methyl ester hydrochrolide (L-NAME), (d) BAY 41-2272 alone, and (e) L-NAME _ BAY 41-2272. The NO synthase blocker L-NAME (20 mg/rat/day) was giving in the drinking water concomitantly or not with BAY 41-2272 (10 mg/kg/day, given by gavage). Results: Chronic L-NAME treatment markedly increased the mean arterial blood pressure (MABP), and co-treatment with BAY 41-2272 nearly reversed L-NAME-induced rise on MABP. Non-void contractions were significantly increased in L-NAME group (0.90 +/- 0.1 number/min) compared with either DMSO or control group (0.49 +/- 0.1 number/min), which were prevented by co-treatment with BAY 41-2271 (0.56 +/- 025 number/min; P < 0.05). The threshold pressure and peak pressure increased by 70% and 44% after chronic L-NAME treatment, while co-treatment with BAY 41-2272 largely attenuated both of these effects (27% and 22% increase, respectively). The frequency of micturition cycles decreased by about of 50% in L-NAMEtreated rats compared with control animals, and co-treatment with BAY 41-2272 normalized this parameter. Conclusions: Our data show that long-term oral administration of BAY 41-2272 counteracts the bladder dysfunction seen in NO-deficient rats, indicating that restoration of the NO-cGMP pathway by this compound may be of beneficial value to treat bladder symptoms. Neurourol. Urodynam. 30: 456-460, 2011. (C) 2011 Wiley-Liss, Inc.
Subject: BAY 41-2272
nitric oxide
overactive bladder
soluble guanylyl cyclase
Country: EUA
Editor: Wiley-blackwell
Citation: Neurourology And Urodynamics. Wiley-blackwell, v. 30, n. 3, n. 456, n. 460, 2011.
Rights: fechado
Identifier DOI: 10.1002/nau.20992
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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