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Type: Artigo de periódico
Title: Factor V Leiden (fvq 506) Is Common In A Brazilian Population
Author: Arruda V.R.
Annichino-Bizzacchi M.
Costa F.F.
Reitsma P.H.
Abstract: Resistance to activated protein C (APC) is the most common risk factor in venous thrombosis. A missense mutation in the factor V gene (factor V Leiden) is the molecular basis for this phenotype. Factor V Leiden was previously found in about 20% of unselected patients with thrombosis but also occurred in 3-5% of healthy Dutch controls. In the present study of Brazilian patients with venous thrombosis we also observed a frequency of 20% for this factor. In addition, in healthy Brazilian controls the frequency of the mutation was 2%. These data suggest that factor V Leiden has a similar distribution worldwide irrespective of the ethnic origin of the population.
Citation: American Journal Of Hematology. , v. 49, n. 3, p. 242 - 243, 1995.
Rights: fechado
Identifier DOI: 10.1002/ajh.2830490312
Date Issue: 1995
Appears in Collections:Unicamp - Artigos e Outros Documentos

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