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Type: Artigo de periódico
Title: Factor V Leiden And Myocardial Infarction In A Brazilian Population
Author: Chiaparme L.C.
Ribeiro C.C.
Silva L.P.
Arruda V.R.
Coelho O.R.
Annichino-Bizzacchi J.M.
Abstract: Myocardial infarction (MI) is commonly precipitated by thrombotic occlusion of a coronary artery complicating atheromatous obstruction and the recognition of hypercoagulability state is important for the management of these patients. Among patients with primary hypercoagulability the resistence to activated protein C is the most frequent cause of unexplained venous thrombosis (20-40% of the cases) and is associated in almost all cases with a unique point mutation in the factor V gene (FV Leiden). Moreover, this mutation also occured in 2-7% of normal controls. In this regard, in heterozygotes, the risk of developing thrombosis is 5-10 fold greater than in the normal population and an increase of 30 fold is also observed among carriers of the mutation in use of oral contraceptives. Previously, we described an incidence of 2% among Brazilian controls of Caucasian descend, and lower than 1% for the Black population and also ocurred in 20% among patients with venous thrombosis. The studies about FV Leiden as a risk factor for MI showed controversial results when women and men were compared, and a high risk was observed only among women associated with smoking. Here we carried out a study in order to determine the incidence of Factor V Leiden in a group of Brazilian patients with Ml. They included 130 patients (32 female/98 male), median age of 50 years, and the distribution among differents ethnic groups was 110 from Caucasian, 19 from Black and 1 from Asian populations.Genomic DNA was extracted from EDTA blood by standard procedures and the FV Leiden mutation was detected by Mnll digestion of the PCR product. Heterozigous for the FV Leiden was found in 5 out of 130 (3,8%) patients. The distribution by sex revelead 4 out of 98 (4,1%) for male and in 1 out of 32 (3,1%) for female. Most of the patients with myocardial infarction, both with and without factor V Leiden, had conventional risk factors for ischaemic heart disease, as tabagism (60%),hyperlipidaemia (80%), diabets (20%), arterial hypertension (70%). Our results demonstrate that the frequency of FV Leiden was slight higher in patients with MI when compared to control group, specially in the male group. However it has no substancial impact as in patients with venous thrombosis. Therefore, this mutation does not appear to increase the risk for the MI but the role of FV Leiden in the evolution of these patients remains to be determined.
Citation: Fibrinolysis. , v. 10, n. SUPPL. 3, p. 130 - , 1996.
Rights: fechado
Date Issue: 1996
Appears in Collections:Unicamp - Artigos e Outros Documentos

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