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Type: Artigo de periódico
Title: Synthesis, Antimycobacterial Activities And Cytotoxicity On V79 Of 3-[4′-y-(1,1′-biphenyl)-4-yl]-n,n-dimethyl-3-(4-x-phenyl)-2- Propen-1-amine Derivatives
Author: De Souza A.O.
Santos Junior R.R.
Ferreira-Julio J.F.
Rodriguez J.A.
Melo P.S.
Haun M.
Sato D.N.
Duran N.
Abstract: The derivatives of 3-(4′-bromo-[1,1′-biphenyl]-4-yl)-3-(4-X-phenyl)-N,N-dimethyl-2- propen-1-amine (5a-m) were synthesised through a Friedel-Crafts acylation followed by Wittig reaction. The effects of the compounds on standard strains of Mycobacterium sp. (ATCC) and M. tuberculosis isolated from clinical specimens were evaluated. Also the toxicity was determined on V79 cells line using neutral red uptake (NRU), nucleic acid content (NAC) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction to measure the cellular viability. © 2001 Éditions scientifiques et médicales Elsevier SAS.
Citation: European Journal Of Medicinal Chemistry. , v. 36, n. 10, p. 843 - 850, 2001.
Rights: fechado
Identifier DOI: 10.1016/S0223-5234(01)01263-6
Date Issue: 2001
Appears in Collections:Unicamp - Artigos e Outros Documentos

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