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Type: Artigo de periódico
Title: Mitochondria And Reactive Oxygen Species
Author: Kowaltowski A.J.
de Souza-Pinto N.C.
Castilho R.F.
Vercesi A.E.
Abstract: Mitochondria are a quantitatively relevant source of reactive oxygen species (ROS) in the majority of cell types. Here we review the sources and metabolism of ROS in this organelle, including the conditions that regulate the production of these species, such as mild uncoupling, oxygen tension, respiratory inhibition, Ca2+ and K+ transport, and mitochondrial content and morphology. We discuss substrate-, tissue-, and organism-specific characteristics of mitochondrial oxidant generation. Several aspects of the physiological and pathological roles of mitochondrial ROS production are also addressed. © 2009 Elsevier Inc. All rights reserved.
Citation: Free Radical Biology And Medicine. , v. 47, n. 4, p. 333 - 343, 2009.
Rights: fechado
Identifier DOI: 10.1016/j.freeradbiomed.2009.05.004
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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