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Type: Artigo de periódico
Title: The Effect Of Soy Dietary Supplement And Low Dose Of Hormone Therapy On Main Cardiovascular Health Biomarkers: A Randomized Controlled Trial [o Efeito De Um Suplemento Alimentar à Base De Soja E Terapia Hormonal Em Baixa Dose Sobre Os Principais Marcadores De Risco Cardiovascular: Ensaio Clínico Randomizado Controlado]
Author: Carmignani L.O.
Pedro A.O.
Da Costa-Paiva L.H.S.
Pinto-Neto A.M.
Abstract: PURPOSE: To assess the effects of a soy dietary supplement on the main biomarkers of cardiovascular health in postmenopausal women compared with the effects of low-dose hormone therapy (HT) and placebo. METHODS: Double-blind, randomized and controlled intention-to-treat trial. Sixty healthy postmenopausal women, aged 40-60 years, 4.1 years mean time since menopause were recruited and randomly assigned to 3 groups: a soy dietary supplement group (isoflavone 90mg), a low-dose HT group (estradiol 1 mg plus noretisterone 0.5 mg) and a placebo group. Lipid profile, glucose level, body mass index, blood pressure and abdominal/hip ratio were evaluated in all the participants at baseline and after 16 weeks. Statistical analyses were performed using the χ2 test, Fisher's exact test, Kruskal-Wallis non-parametric test, analysis of variance (ANOVA), paired Student's t-test and Wilcoxon test. RESULTS: After a 16-week intervention period, total cholesterol decreased 11.3% and LDL-cholesterol decreased 18.6% in the HT group, but both did not change in the soy dietary supplement and placebo groups. Values for triglycerides, HDL-cholesterol, glucose level, body mass index, blood pressure and abdominal/hip ratio did not change over time in any of the three groups. CONCLUSION: The use of dietary soy supplement did not show any significant favorable effect on cardiovascular health biomarkers compared with HT.
Editor: Federacao Brasileira das Sociedades de Ginecologia e Obstetricia
Citation: Revista Brasileira De Ginecologia E Obstetricia. Federacao Brasileira Das Sociedades De Ginecologia E Obstetricia, v. 36, n. 6, p. 251 - 258, 2014.
Rights: aberto
Identifier DOI: 10.1590/S0100-720320140004976
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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