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|Type:||Artigo de evento|
|Title:||Ha/tcp Scaffolds Coated By Pla And Gelatin: Preliminary In Vitro Evaluation|
De Carvalho Zavaglia C.A.
|Abstract:||Tissue engineering is an interdisciplinary field that applies biological and engineering knowledge to develop replacement tissue, for example, bone tissue. Normally, scaffolds are used to provide a support for cell migration, attachment, and proliferation. However, biomimetic surface modification of scaffolds has proved to be an improvement of interaction between materials and biological tissues. These changes can induce a specific cellular response and thereby enhance the desired effects. This paper describes fabrication and coating processes of scaffolds. The coating process consist in immersed the scaffold in solutions of PLA and gelatin, followed evaporative drying in ambient temperature. For characterization were used: scanning electron microscopy (SEM), optical microscopy (OP), stereoscopy, transmission electron microscopy (TEM), X-ray microtomography (Micro-CT), X-ray diffraction (XRD) and X-ray fluorescence (XRF). The bioceramic materials used in this work showed particles size between 10 and 45 nm, and low chemical contamination. The scaffolds showed morphology with adequate porosity for tissue engineering. We suggest that the particle size used improved the process of polymer foam replication, and the coated scaffolds showed evidence of not being cytotoxic.|
|Editor:||Trans Tech Publications Ltd|
|Citation:||Key Engineering Materials. Trans Tech Publications Ltd, v. 631, n. , p. 289 - 294, 2015.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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