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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleModeling, Simulation, and Experimental Evaluation of Continuous Chromatographic Separation of Ketamine Enantiomers on MCTApt_BR
dc.contributor.authorBarreto, AGpt_BR
dc.contributor.authorda Silva, IJpt_BR
dc.contributor.authordos Santos, MAGpt_BR
dc.contributor.authorde Veredas, Vpt_BR
dc.contributor.authorSantana, CCpt_BR
unicamp.author.emailsantana@feq.unicamp.brpt_BR
unicamp.authorGarcia dos Santos, Marco Antonio de Veredas, Vinicius Santana, Cesar Costapinto Univ Estadual Campinas, Fac Engn Quim, Dept Proc Biotecnol, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorBarreto, Amaro Gomes, Jr. Univ Fed Rio de Janeiro, Escola Quim, Edificio Ctr Technol, Dept Engn Quim, Rio De Janeiro, Brazilpt_BR
unicamp.authorda Silva, Ivanildo Jose, Jr. Univ Fed Cerara, Ctr Technol, Dept Engn Quim, GPSA, Fortaleza, Ceara, Brazilpt_BR
dc.subjectChiral separationpt_BR
dc.subjectEquilibrium theorypt_BR
dc.subjectKetaminept_BR
dc.subjectLiquid chromatographypt_BR
dc.subjectSimulated moving bedpt_BR
dc.subject.wosMoving-bed Chromatographypt_BR
dc.subject.wosLiquid-chromatographypt_BR
dc.subject.wosPerformancept_BR
dc.subject.wosNorketaminept_BR
dc.subject.wosOperationpt_BR
dc.subject.wosPlasmapt_BR
dc.subject.wosPhasept_BR
dc.subject.wosUnitspt_BR
dc.description.abstractResults on the chiral separation of ketamine enantiomers by simulated moving bed (SMB) chromatography using microcrystalline cellulose triacetate (MCTA) columns are reported. Experimental data obtained with the SMB laboratory unit showed purities above 99.5% in the raffinate stream and above 97.7% in the extract stream. A simulation approach based on true moving bed (TMB) was applied to validate the performance of the SMB in steady state regime, taking into account the non-linear isotherms, non-ideal effects, and the non-homogeneities of the eight columns. The experimental and calculated results are in agreement with the internal profiles calculated by the TMB approach.pt
dc.relation.ispartofJournal Of Liquid Chromatography & Related Technologiespt_BR
dc.relation.ispartofabbreviationJ. Liq. Chromatogr. Relat. Technol.pt_BR
dc.publisher.cityPhiladelphiapt_BR
dc.publisher.countryEUApt_BR
dc.publisherTaylor & Francis Incpt_BR
dc.date.issued2008pt_BR
dc.identifier.citationJournal Of Liquid Chromatography & Related Technologies. Taylor & Francis Inc, v. 31, n. 20, n. 3057, n. 3076, 2008.pt_BR
dc.language.isoenpt_BR
dc.description.volume31pt_BR
dc.description.issuenumber20pt_BR
dc.description.firstpage3057pt_BR
dc.description.lastpage3076pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asppt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn1082-6076pt_BR
dc.identifier.wosidWOS:000260260500001pt_BR
dc.identifier.doi10.1080/10236660802479507pt_BR
dc.description.sponsorshipFinep [77.97.0503.00]pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsordocumentnumberFinep [77.97.0503.00]pt
dc.description.sponsordocumentnumberCNPq [465707/200-9)]pt
dc.description.sponsordocumentnumberFAPESP [2001/13168-0, 2006/02511-9]pt
dc.date.available2014-11-18T18:32:34Z
dc.date.available2015-11-26T16:57:47Z-
dc.date.accessioned2014-11-18T18:32:34Z
dc.date.accessioned2015-11-26T16:57:47Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T16:57:47Z (GMT). No. of bitstreams: 2 WOS000260260500001.pdf: 794989 bytes, checksum: b1a470a159e5044d27b89789d972aa98 (MD5) WOS000260260500001.pdf.txt: 39615 bytes, checksum: 216454140fe1616545515d2d787ac127 (MD5) Previous issue date: 2008en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/82329pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/82329
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/82329-
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