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Type: Artigo de periódico
Title: Modeling, Simulation, and Experimental Evaluation of Continuous Chromatographic Separation of Ketamine Enantiomers on MCTA
Author: Barreto, AG
da Silva, IJ
dos Santos, MAG
de Veredas, V
Santana, CC
Abstract: Results on the chiral separation of ketamine enantiomers by simulated moving bed (SMB) chromatography using microcrystalline cellulose triacetate (MCTA) columns are reported. Experimental data obtained with the SMB laboratory unit showed purities above 99.5% in the raffinate stream and above 97.7% in the extract stream. A simulation approach based on true moving bed (TMB) was applied to validate the performance of the SMB in steady state regime, taking into account the non-linear isotherms, non-ideal effects, and the non-homogeneities of the eight columns. The experimental and calculated results are in agreement with the internal profiles calculated by the TMB approach.
Subject: Chiral separation
Equilibrium theory
Liquid chromatography
Simulated moving bed
Country: EUA
Editor: Taylor & Francis Inc
Citation: Journal Of Liquid Chromatography & Related Technologies. Taylor & Francis Inc, v. 31, n. 20, n. 3057, n. 3076, 2008.
Rights: fechado
Identifier DOI: 10.1080/10236660802479507
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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