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Type: Artigo de periódico
Title: Optimized Enzymatic Synthesis of Hesperidin Fatty Acid Esters in a Two-Phase System Containing Ionic Liquid
Author: de Araujo, MEMB
Contesini, FJ
Franco, YEM
Sawaya, ACHF
Alberto, TG
Dalfre, N
Carvalho, PD
Abstract: Response surface methodology (RSM) based on a five-level, three-variable central composite design (CCD) was employed for modeling and optimizing the conversion yield of the enzymatic acylation of hesperidin with decanoic acid using immobilized Candida antarctica lipase B (CALB) in a two-phase system containing [bmim]BF(4). The three variables studied (molar ratio of hesperidin to decanoic acid, [bmim]BF(4)/acetone ratio and lipase concentration) significantly affected the conversion yield of acylated hesperidin derivative. Verification experiments confirmed the validity of the predicted model. The lipase showed higher conversion degree in a two-phase system using [bmim] BF4 and acetone compared to that in pure acetone. Under the optimal reaction conditions carried out in a single-step biocatalytic process when the water content was kept lower than 200 ppm, the maximum acylation yield was 53.6%.
Subject: Candida antarctica
Country: Suíça
Editor: Mdpi Ag
Citation: Molecules. Mdpi Ag, v. 16, n. 8, n. 7171, n. 7182, 2011.
Rights: aberto
Identifier DOI: 10.3390/molecules16087171
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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