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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleLymphatic vascular density and lymphangiogenesis during tumour progression of carcinoma ex pleomorphic adenomapt_BR
dc.contributor.authorSoares, ABpt_BR
dc.contributor.authorPonchio, Lpt_BR
dc.contributor.authorJuliano, PBpt_BR
dc.contributor.authorAraujo, VCpt_BR
dc.contributor.authorAltemani, Apt_BR
unicamp.authorUniv Estadual Campinas, Dept Pathol, Sch Med, BR-13081 Campinas, SP, Brazil Ctr Pesquisa Sao Leopoldo Mandic, Campinas, Brazilpt_BR
dc.subject.wosSquamous-cell Carcinomapt_BR
dc.subject.wosMalignant Mixed Tumorspt_BR
dc.subject.wosVessel Densitypt_BR
dc.subject.wosCutaneous Melanomapt_BR
dc.subject.wosPrognostic Valuept_BR
dc.subject.wosUterine Cervixpt_BR
dc.description.abstractAims: To assess lymphatic vascular density (LVD) and lymph vessel endothelial proliferation in a series of carcinoma ex pleomorphic adenoma ( CXPA) that represents the tumour in the different carcinogenesis phases and tumour progression. Methods: In 8 cases of early CXPA ( intracapsular and minimally invasive tumours), 8 of advanced CXPA ( widely invasive tumours) and 10 of pleomorphic adenoma (PA) without malignant transformation, lymphatic vessels and proliferating cells were detected using the antibodies D2-40 and Ki-67 respectively. Results: Comparing early tumours with advanced ones, LVD was not significantly different at the tumour margin. In contrast, regarding intratumoural lymphatics, PA without malignant transformation and early CXPA contained rare, if any, lymph vessels, whereas in widely invasive carcinomas they were more numerous. However, neither intratumoural nor peritumoural LVD were increased in comparison to adjacent normal salivary gland tissue. In no case did dual immunohistochemistry using D2-40 and the cell proliferation marker Ki-67 reveal the existence of proliferating lymphatics. Carcinomatous emboli were found in peritumoural as well as in intratumoural lymphatics only in advanced CXPA without myoepithelial differentiation. Conclusion: In CXPA, the lymphatic network is mainly composed of pre-existing lymphatics which are rare in tumours that have not infiltrated outside the confines of the original PA. In the widely invasive CXPA, intratumoural as well as peritumoural lymphatics are a conduit for carcinoma cells, but in carcinomas with myoepithelial differentiation, the neoplastic cells seem to have a lower invasion
dc.relation.ispartofJournal Of Clinical Pathologypt_BR
dc.relation.ispartofabbreviationJ. Clin. Pathol.pt_BR
dc.publisherB M J Publishing Grouppt_BR
dc.identifier.citationJournal Of Clinical Pathology. B M J Publishing Group, v. 60, n. 9, n. 995, n. 1000, 2007.pt_BR
dc.sourceWeb of Sciencept_BR
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