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Type: Artigo de periódico
Title: Preliminary studies on the antibacterial activity of crude extracts and alkaloids from species of Aspidosperma
Author: de Oliveira, AJB
Koike, L
Reis, FDM
Eguchi, SY
Endo, EH
Nakamura, CV
Dias, BP
Abstract: Screening tests of hydroethanolic crude extracts of six species of Aspidosperma (Apocynaceae) against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Pseudomonas aeruginosa were performed. Aspidosperma ramiflorum Muell. Arg. showed good activity against Bacillus subtilis with MIC and MBC of 15.7 and 125 mu g/mL, moderate activity against Staphylococcus aureus with MIC and MBC of 250 and 500 mu g/mL, and weak activity against Escherichia coli with MIC and MBC of 1000 mu g/mL. Aspidosperma pyricolum Muell. Arg. (MIC/MBC 125/250 mu g/mL) and Aspidosperma olivaceum Muell. Arg. (MIC/MBC 250/> 1000 mu g/mL) displayed moderate antibacterial activity against Bacillus subtilis. Separation of the crude extract of Aspidosperma ramiflorum was performed according to the usual acid-base process, which produces alkaloid mixtures and closely related metabolites. The basic fraction was active against Bacillus subtilis, Staphylococcus aureus, and Escherichia coli, with MICs of 31.2, 62.5, and 250 mu g/mL, respectively. The basic fractions were more active than the acid fractions, probably because they contained some active alkaloids and/or closely related metabolites absent from the other fractions, or they contained a higher concentration of these active compounds.
Subject: Alkaloids
antibacterial activity
stem bark
Country: EUA
Editor: Taylor & Francis Inc
Citation: Pharmaceutical Biology. Taylor & Francis Inc, v. 47, n. 11, n. 1085, n. 1089, 2009.
Rights: fechado
Identifier DOI: 10.3109/13880200903008633
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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