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Type: Artigo de periódico
Title: Levels and patterns of expression of hypoxia-inducible factor-1a, vascular endothelial growth factor, glucose transporter-1 and CD105 in adenoid cystic carcinomas with high-grade transformation
Author: Costa, AF
Tasso, MG
Mariano, FV
Soares, AB
Chone, CT
Crespo, AN
Fresno, MF
Llorente, JL
Suarez, C
de Araujo, VC
Hermsen, M
Altemani, A
Abstract: Aims: To compare the expression of proteins regulated by hypoxia between adenoid cystic carcinoma (ACC) with and without high-grade transformation (HGT). Methods and results: In eight ACC-HGT and 18 ACC without HGT, expression of hypoxia-inducible factor-1 (HIF-1a), vascular endothelial growth factor (VEGF), glucose transporter-1 (GLUT-1) and microvascular density (MVD) by CD105 (a hypoxia-inducible protein expressed in angiogenic endothelial cells) was determined. Expression levels of HIF-1a and VEGF as well as CD105-MVD did not differ significantly between: (i) transformed and conventional areas (TA and CA, respectively) of ACC-HGT, (ii) CA and ordinary ACC. HIF-1a was detected in 100% of cases and presented a diffuse expression pattern. No significant association was found between levels of HIF-1a expression and tumour size, metastasis and recurrence. GLUT-1 showed a prostromal expression pattern and was observed exclusively in TA (three of six cases) and in only three of 14 ACC. Conclusions: Both the absence of significant alterations in levels of expression of HIF-1a, VEGF and CD105 and the patterns of expression of HIF-1a and GLUT-1 suggest that hypoxia may not play a key role in the process of high-grade transformation of ACC. Although HIF-1a expression is a common finding in ACC, it cannot be used as a marker of tumour aggressiveness.
Subject: adenoid cystic carcinoma
glucose transporter-1
high-grade transformation
hypoxia-inducible factor-1
vascular endothelial growth factor
Country: EUA
Editor: Wiley-blackwell
Citation: Histopathology. Wiley-blackwell, v. 60, n. 5, n. 816, n. 825, 2012.
Rights: fechado
Identifier DOI: 10.1111/j.1365-2559.2011.04128.x
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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