Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/80122
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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleRelationship between environmental factors and gray matter atrophy in refractory MTLEpt_BR
dc.contributor.authorYasuda, CLpt_BR
dc.contributor.authorMorita, MEpt_BR
dc.contributor.authorAlessio, Apt_BR
dc.contributor.authorPereira, ARpt_BR
dc.contributor.authorBalthazar, MLFpt_BR
dc.contributor.authorSaude, AVpt_BR
dc.contributor.authorCosta, ALFpt_BR
dc.contributor.authorCosta, ALCpt_BR
dc.contributor.authorCardoso, TApt_BR
dc.contributor.authorBetting, LEpt_BR
dc.contributor.authorGuerreiro, CAMpt_BR
dc.contributor.authorDamasceno, BPpt_BR
dc.contributor.authorLopes-Cendes, Ipt_BR
dc.contributor.authorTedeschi, Hpt_BR
dc.contributor.authorde Oliveira, Ept_BR
dc.contributor.authorCendes, Fpt_BR
unicamp.author.emailfcendes@unicamp.brpt_BR
unicamp.authorYasuda, C. L. Morita, M. E. Alessio, A. Balthazar, M. L. F. Costa, A. L. C. Cardoso, T. A. Betting, L. E. Guerreiro, C. A. M. Damasceno, B. P. Tedeschi, H. de Oliveira, E. Cendes, F. Univ Estadual Campinas, Dept Neurol, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorYasuda, C. L. Morita, M. E. Alessio, A. Balthazar, M. L. F. Costa, A. L. F. Betting, L. E. Cendes, F. Univ Estadual Campinas, Lab Neuroimaging, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorPereira, A. R. Univ Estadual Campinas, Fac Med Sci, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorLopes-Cendes, I. Univ Estadual Campinas, Dept Med Genet, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorSaude, A. V. Lopes-Cendes, I. Univ Fed Lavras, Dept Comp Sci, Lavras, Brazilpt_BR
dc.subject.wosTemporal-lobe Epilepsypt_BR
dc.subject.wosVoxel-based Morphometrypt_BR
dc.subject.wosHippocampal Atrophypt_BR
dc.subject.wosMemorypt_BR
dc.subject.wosSclerosispt_BR
dc.subject.wosSurgerypt_BR
dc.subject.wosBrainpt_BR
dc.subject.wosMicrodysgenesispt_BR
dc.subject.wosNormalizationpt_BR
dc.subject.wosIntelligencept_BR
dc.description.abstractObjective: To investigate clinical, neuropsychological, and MRI abnormalities (gray matter atrophy [GMA] and white matter atrophy [WMA]) in surgical mesial temporal lobe epilepsy (MTLE) patients with and without familial antecedent for epilepsy. Methods: A cohort study including 69 operated patients with unilateral MTLE, divided into a group of 29 patients (mean age 35.8 +/- 10.4 years) with a negative family history (FH) of epilepsy and a group of 40 patients (32.8 +/- 10 years) with a positive FH. We performed voxel-based morphometry (VBM) on preoperative MRIs and investigated possible clinical and neuropsychological differences between the 2 groups. We also performed VBM and t tests to compare the patients' groups with normal controls. Results: The negative-FH group had lower IQ scores (p = 0.004), performed poorer on the Boston Naming Test (p = 0.02) and on delayed recall (p = 0.03), and presented a more prominent asymmetry index of hippocampal volume (p = 0.04) and more frequent initial precipitating injuries (p = 0.023). VBM showed a more restricted pattern of GMA in the positive-FH group and a more bilateral and widespread pattern of GMA in the negative-FH group, involving thalami, temporal, frontal, parietal, and occipital lobes. WMA was widespread and bilateral in both groups. Conclusions: The more widespread structural voxel-based morphometry abnormalities and worse IQ performance identified in the negative-family history (FH) group may result from a stronger environmental influence, including initial precipitating injuries. This is further support for the hypothesis that hippocampal sclerosis in mesial temporal lobe epilepsy with positive FH is determined by a stronger genetic predisposition with less influence of environmental factors compared with patients in the negative-FH group. Neurology(R) 2010;74:1062-1068pt
dc.description.noteo TEXTO COMPLETO DESTE ARTIGO, ESTARÁ DISPONÍVEL À PARTIR DE AGOSTO DE 2015.pt
dc.relation.ispartofNeurologypt_BR
dc.relation.ispartofabbreviationNeurologypt_BR
dc.publisher.cityPhiladelphiapt_BR
dc.publisher.countryEUApt_BR
dc.publisherLippincott Williams & Wilkinspt_BR
dc.date.issued2010pt_BR
dc.date.monthofcirculation11018pt_BR
dc.identifier.citationNeurology. Lippincott Williams & Wilkins, v. 74, n. 13, n. 1062, n. 1068, 2010.pt_BR
dc.language.isoenpt_BR
dc.description.volume74pt_BR
dc.description.issuenumber13pt_BR
dc.description.firstpage1062pt_BR
dc.description.lastpage1068pt_BR
dc.rightsembargopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0028-3878pt_BR
dc.identifier.wosidWOS:000276255500011pt_BR
dc.identifier.doi10.1212/WNL.0b013e3181d76b72pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipNovartispt_BR
dc.description.sponsorshipJanssen-Cilagpt_BR
dc.description.sponsorshipGlaxoSmithKlinept_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2014-11-15T09:01:54Z
dc.date.available2015-11-26T17:19:14Z-
dc.date.accessioned2014-11-15T09:01:54Z
dc.date.accessioned2015-11-26T17:19:14Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T17:19:14Z (GMT). No. of bitstreams: 2 WOS000276255500011.pdf: 1198604 bytes, checksum: aebc23e93cb70bbcdfd66460a5a13d45 (MD5) WOS000276255500011.pdf.txt: 36139 bytes, checksum: 4c5cff682c1daa6eba8f7f7eb1554a37 (MD5) Previous issue date: 2010en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/80122pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/80122
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/80122-
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