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Type: Artigo de periódico
Title: Disappearance of cerebrospinal fluid oligoclonal bands after natalizumab treatment of multiple sclerosis patients
Author: von Glehn, F
Farias, AS
de Oliveira, ACP
Damasceno, A
Longhini, ALF
Oliveira, EC
Damasceno, BP
Santos, LMB
Brandao, CO
Abstract: Intrathecal immunoglobulin synthesis in an oligoclonal pattern is the most common immunologic abnormality detected in MS patients. Various treatments, such as immunomodulators and immunosuppressors, have not been found to modify it. Natalizumab hinders migration of encephalitogenic T-cells into the central nervous system (CNS), reducing inflammatory response. Its impact on CSF oligoclonal bands (OCBs) has not been demonstrated. This report describes its effect in four out of six patients with multiple sclerosis after a mean of 10 infusions: the CSF was negative for OCBs at the second lumbar puncture. In conclusion, natalizumab treatment can reduce CSF OCBs to undetectable levels, although the clinical significance of this observation is not yet known.
Subject: cerebrospinal fluid
multiple sclerosis
natalizumab therapy
oligoclonal bands
Country: Inglaterra
Editor: Sage Publications Ltd
Citation: Multiple Sclerosis Journal. Sage Publications Ltd, v. 18, n. 7, n. 1038, n. 1041, 2012.
Rights: fechado
Identifier DOI: 10.1177/1352458511428465
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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