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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleDefault Mode, Executive Function, and Language Functional Connectivity Networks are Compromised in Mild Alzheimer's Diseasept_BR
dc.contributor.authorWeiler, Mpt_BR
dc.contributor.authorFukuda, Apt_BR
dc.contributor.authorMassabki, LHPpt_BR
dc.contributor.authorLopes, TMpt_BR
dc.contributor.authorFranco, ARpt_BR
dc.contributor.authorDamasceno, BPpt_BR
dc.contributor.authorCendes, Fpt_BR
dc.contributor.authorBalthazar, MLFpt_BR
unicamp.author.emailmbalth@unicamp.brpt_BR
unicamp.authorWeiler, Marina Fukuda, Aya Massabki, Lilian H. P. Lopes, Tatila M. Cendes, Fernando Balthazar, Marcio L. F. Univ Campinas UNICAMP, Dept Neurol, Neuroimaging Lab, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorDamasceno, Benito P. Balthazar, Marcio L. F. Univ Campinas UNICAMP, Dept Neurol, Unit Neuropsychol & Neurolinguist, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorFranco, Alexandre R. Catholic Univ Rio Grande Sul PUCRS, Brain Inst Rio Grande Sul, Porto Alegre, RS, Brazilpt_BR
dc.subjectAlzheimer's diseasept_BR
dc.subjectcognitionpt_BR
dc.subjectdefault mode networkpt_BR
dc.subjectfunctional connectivitypt_BR
dc.subjectfunctional networkspt_BR
dc.subjectresting-state networkspt_BR
dc.subject.wosResting-state Networkspt_BR
dc.subject.wosCognitive Impairmentpt_BR
dc.subject.wosBrainpt_BR
dc.subject.wosDisruptionpt_BR
dc.subject.wosFmript_BR
dc.subject.wosIndividualspt_BR
dc.subject.wosProgressionpt_BR
dc.subject.wosDementiapt_BR
dc.subject.wosAtrophypt_BR
dc.subject.wosThoughtpt_BR
dc.description.abstractAlzheimer's disease (AD) is characterized by mental and cognitive problems, particularly with memory, language, visuospatial skills (VS), and executive functions (EF). Advances in the neuroimaging of AD have highlighted dysfunctions in functional connectivity networks (FCNs), especially in the memory related default mode network (DMN). However, little is known about the integrity and clinical significance of FNCs that process other cognitive functions than memory. We evaluated 22 patients with mild AD and 26 healthy controls through a resting state functional MRI scan. We aimed to identify different FCNs: the DMN, language, EF, and VS. Seed-based functional connectivity was calculated by placing a seed in the DMN (posterior cingulate cortex), language (Broca's and Wernicke's areas), EF (right and left dorsolateral prefrontal cortex), and VS networks (right and left associative visual cortex). We also performed regression analyses between individual connectivity maps for the different FCNs and the scores on cognitive tests. We found areas with significant decreases in functional connectivity in patients with mild AD in the DMN and Wernicke's area compared with controls. Increased connectivity in patients was observed in the EF network. Regarding multiple linear regression analyses, a significant correlation was only observed between the connectivity of the DMN and episodic memory (delayed recall) scores. In conclusion, functional connectivity alterations in mild AD are not restricted to the DMN. Other FCNs related to language and EF may be altered. However, we only found significant correlations between cognition and functional connectivity in the DMN and episodic memory performance.pt
dc.relation.ispartofCurrent Alzheimer Researchpt_BR
dc.relation.ispartofabbreviationCurr. Alzheimer Res.pt_BR
dc.publisher.citySharjahpt_BR
dc.publisher.countryEmirados Árabes Unidospt_BR
dc.publisherBentham Science Publ Ltdpt_BR
dc.date.issued2014pt_BR
dc.date.monthofcirculationMARpt_BR
dc.identifier.citationCurrent Alzheimer Research. Bentham Science Publ Ltd, v. 11, n. 3, n. 274, n. 282, 2014.pt_BR
dc.language.isoenpt_BR
dc.description.volume11pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage274pt_BR
dc.description.lastpage282pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn1567-2050pt_BR
dc.identifier.eissn1875-5828pt_BR
dc.identifier.wosidWOS:000334058100008pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsordocumentnumberFAPESP [2011/17092-0, 2013/10431-9]pt
dc.date.available2014-08-01T18:28:02Z
dc.date.available2015-11-26T17:56:28Z-
dc.date.accessioned2014-08-01T18:28:02Z
dc.date.accessioned2015-11-26T17:56:28Z-
dc.description.provenanceMade available in DSpace on 2014-08-01T18:28:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:56:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/79364
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/79364-
Appears in Collections:Unicamp - Artigos e Outros Documentos

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