Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleDefault Mode, Executive Function, and Language Functional Connectivity Networks are Compromised in Mild Alzheimer's Diseasept_BR
dc.contributor.authorWeiler, Mpt_BR
dc.contributor.authorFukuda, Apt_BR
dc.contributor.authorMassabki, LHPpt_BR
dc.contributor.authorLopes, TMpt_BR
dc.contributor.authorFranco, ARpt_BR
dc.contributor.authorDamasceno, BPpt_BR
dc.contributor.authorCendes, Fpt_BR
dc.contributor.authorBalthazar, MLFpt_BR
unicamp.authorWeiler, Marina Fukuda, Aya Massabki, Lilian H. P. Lopes, Tatila M. Cendes, Fernando Balthazar, Marcio L. F. Univ Campinas UNICAMP, Dept Neurol, Neuroimaging Lab, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorDamasceno, Benito P. Balthazar, Marcio L. F. Univ Campinas UNICAMP, Dept Neurol, Unit Neuropsychol & Neurolinguist, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorFranco, Alexandre R. Catholic Univ Rio Grande Sul PUCRS, Brain Inst Rio Grande Sul, Porto Alegre, RS, Brazilpt_BR
dc.subjectAlzheimer's diseasept_BR
dc.subjectdefault mode networkpt_BR
dc.subjectfunctional connectivitypt_BR
dc.subjectfunctional networkspt_BR
dc.subjectresting-state networkspt_BR
dc.subject.wosResting-state Networkspt_BR
dc.subject.wosCognitive Impairmentpt_BR
dc.description.abstractAlzheimer's disease (AD) is characterized by mental and cognitive problems, particularly with memory, language, visuospatial skills (VS), and executive functions (EF). Advances in the neuroimaging of AD have highlighted dysfunctions in functional connectivity networks (FCNs), especially in the memory related default mode network (DMN). However, little is known about the integrity and clinical significance of FNCs that process other cognitive functions than memory. We evaluated 22 patients with mild AD and 26 healthy controls through a resting state functional MRI scan. We aimed to identify different FCNs: the DMN, language, EF, and VS. Seed-based functional connectivity was calculated by placing a seed in the DMN (posterior cingulate cortex), language (Broca's and Wernicke's areas), EF (right and left dorsolateral prefrontal cortex), and VS networks (right and left associative visual cortex). We also performed regression analyses between individual connectivity maps for the different FCNs and the scores on cognitive tests. We found areas with significant decreases in functional connectivity in patients with mild AD in the DMN and Wernicke's area compared with controls. Increased connectivity in patients was observed in the EF network. Regarding multiple linear regression analyses, a significant correlation was only observed between the connectivity of the DMN and episodic memory (delayed recall) scores. In conclusion, functional connectivity alterations in mild AD are not restricted to the DMN. Other FCNs related to language and EF may be altered. However, we only found significant correlations between cognition and functional connectivity in the DMN and episodic memory
dc.relation.ispartofCurrent Alzheimer Researchpt_BR
dc.relation.ispartofabbreviationCurr. Alzheimer Res.pt_BR
dc.publisher.countryEmirados Árabes Unidospt_BR
dc.publisherBentham Science Publ Ltdpt_BR
dc.identifier.citationCurrent Alzheimer Research. Bentham Science Publ Ltd, v. 11, n. 3, n. 274, n. 282, 2014.pt_BR
dc.sourceWeb of Sciencept_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsordocumentnumberFAPESP [2011/17092-0, 2013/10431-9]pt
dc.description.provenanceMade available in DSpace on 2014-08-01T18:28:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:56:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.