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Type: Artigo de periódico
Title: Decreased CD1a(+), CD83(+) and factor XIIIa(+) dendritic cells in cervical lymph nodes and palatine tonsils of AIDS patients
Author: Gondak, R
Mauad, T
Schultz, L
Soares, F
Kowalski, LP
Vargas, PA
Abstract: AimsThe purpose of this study was to quantify and compare the density of dendritic cells (DCs) in cervical lymph nodes (LNs) and palatine tonsils (PTs) of AIDS and non-AIDS patients. Methods and resultsFactor XIIIa, CD1a and CD83 antibodies were used to identify migratory DCs by immunohistochemistry in LNs and PTs of 32 AIDS patients and 21 HIV-negative control patients. Quantification was performed by the positive pixel count analytical method. AIDS patients presented a lower density of factor XIIIa(+) cells (P<0.001), CD1a(+) cells (P<0.05) and CD83(+) cells (P<0.001) in cervical LNs and PTs compared to the non-AIDS control group. ConclusionOverall depletion of DCs in lymphoid tissues of AIDS patients may be predictive of the immune system's loss of disease control.
Subject: AIDS
dendritic cell
lymph node
palatine tonsil
Country: EUA
Editor: Wiley-blackwell
Citation: Histopathology. Wiley-blackwell, v. 64, n. 2, n. 234, n. 241, 2014.
Rights: fechado
Identifier DOI: 10.1111/his.12256
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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