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Type: Artigo de periódico
Title: Tetrahydrofuran lignans from Nectandra megapotamica with trypanocidal activity
Author: da Silva, AA
Albuquerque, S
Silva, MLAE
Eberlin, MN
Tomazela, DM
Bastos, JK
Abstract: The phytochemical investigation of the crude ethanol extract of the leaves of Nectandra megapotamica afforded three new (2d, 3b, and 3c) and eight known (1a-d, 2a-c, and 3a) tetrahydrofuran lignans. Regarding the in vitro trypanocidal activity, the lignan-rich fraction, at a concentration of 2.0 mg/mL, was 100% active. Compound 1a was the most active, showing an IC50 value of 2.2 muM and lysis of 94% of the parasites at 32 muM. Compounds 1b, 1d, 2a, 2c, and 3a displayed moderate activity, while compound 1c was inactive.
Country: EUA
Editor: Amer Chemical Soc
Citation: Journal Of Natural Products. Amer Chemical Soc, v. 67, n. 1, n. 42, n. 45, 2004.
Rights: fechado
Identifier DOI: 10.1021/np0302697
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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