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Type: Artigo de periódico
Title: Apoptosis-regulating proteins and prognosis in diffuse large B cell non-Hodgkin's lymphomas
Author: Pagnano, KBB
Silva, MD
Vassallo, J
Aranha, FJP
Saad, STO
Abstract: We evaluated the expression of apoptosis-regulating proteins (p53, Bcl-2, Bax, Bak and Mcl-1) in paraffin-embedded tissues of 33 patients with diffuse large B cell non-Hodgkin's lymphoma, and assessed the relationship of these proteins to clinical outcome and response to chemotherapy. Our results showed that p53 expression was an independent immunohistochemical parameter related to a poor prognosis in these lymphomas. Bcl-2, Bax, Bak and Mcl-1 proteins, though highly expressed in almost all cases were not associated with prognosis or response to treatment. Copyright (C) 2002 S. Karger AG, Basel.
Subject: Bcl-2
non-Hodgkin's lymphoma
Country: Suíça
Editor: Karger
Citation: Acta Haematologica. Karger, v. 107, n. 1, n. 29, n. 34, 2002.
Rights: fechado
Identifier DOI: 10.1159/000046626
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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