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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleAntiulcerogenic activity of some sesquiterpene lactones isolated from Artemisia annuapt_BR
dc.contributor.authorFoglio, MApt_BR
dc.contributor.authorDias, PCpt_BR
dc.contributor.authorAntonio, MApt_BR
dc.contributor.authorPossenti, Apt_BR
dc.contributor.authorRodrigues, RAFpt_BR
dc.contributor.authorda Silva, EFpt_BR
dc.contributor.authorRehder, VLGpt_BR
dc.contributor.authorde Carvalho, JEpt_BR
unicamp.authorUniv Estadual Campinas, UNICAMP, CPQBA, Ctr Pluridisciplinar Pesquisas Quim Biol & Agrico, Campinas, SP, Brazil Univ Estadual Campinas, Fac Ciencias Med, Dept Clin Med, UNICAMP,FCM, Campinas, SP, Brazilpt_BR
dc.subjectArtemisia annuapt_BR
dc.subjectAsteraceaept_BR
dc.subjectantiulcer activitypt_BR
dc.subjectsesquiterpenespt_BR
dc.subject.wosGastric-mucosal Lesionspt_BR
dc.subject.wosCytoprotectionpt_BR
dc.subject.wosRatspt_BR
dc.description.abstractArtemisinin 1, dihydro-epideoxyarteannuin B 2 and deoxyartemisinin 3 were isolated from the sequiterpene lactone-enriched fraction obtained from the crude ethanolic extract of Artemisia annua L. These compounds were tested on ethanol and indomethacin-induced ulcer models. Compound 1 did not afford cytoprotection under the experimental models tested. Only compounds 2 and 3 decreased the ulcerative lesion index produced by ethanol and indomethacin in rats. These compounds did not demonstrate antiulcerogenic activity when tested on the ethanol-induced ulcer model, with previous administration of indomethacin, suggesting that the antiulcerogenic activity is a consequence of prostaglandin synthesis increase.pt
dc.relation.ispartofPlanta Medicapt_BR
dc.relation.ispartofabbreviationPlanta Med.pt_BR
dc.publisher.cityStuttgartpt_BR
dc.publisher.countryAlemanhapt_BR
dc.publisherGeorg Thieme Verlag Kgpt_BR
dc.date.issued2002pt_BR
dc.date.monthofcirculationJUNpt_BR
dc.identifier.citationPlanta Medica. Georg Thieme Verlag Kg, v. 68, n. 6, n. 515, n. 518, 2002.pt_BR
dc.language.isoenpt_BR
dc.description.volume68pt_BR
dc.description.issuenumber6pt_BR
dc.description.firstpage515pt_BR
dc.description.lastpage518pt_BR
dc.rightsabertopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0032-0943pt_BR
dc.identifier.wosidWOS:000176898700008pt_BR
dc.identifier.doi10.1055/s-2002-32570pt_BR
dc.date.available2014-11-15T11:07:05Z
dc.date.available2015-11-26T17:19:33Z-
dc.date.accessioned2014-11-15T11:07:05Z
dc.date.accessioned2015-11-26T17:19:33Z-
dc.description.provenanceMade available in DSpace on 2014-11-15T11:07:05Z (GMT). No. of bitstreams: 1 WOS000176898700008.pdf: 77399 bytes, checksum: f150376eaf42b43e0db2f0962624401a (MD5) Previous issue date: 2002en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:19:33Z (GMT). No. of bitstreams: 2 WOS000176898700008.pdf: 77399 bytes, checksum: f150376eaf42b43e0db2f0962624401a (MD5) WOS000176898700008.pdf.txt: 16836 bytes, checksum: 413037e773cb8dcafe6db23024f21c8c (MD5) Previous issue date: 2002en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77990pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/77990
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77990-
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