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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleAnti-inflammatory effect of lycopene on carrageenan-induced paw oedema and hepatic ischaemia-reperfusion in the ratpt_BR
dc.contributor.authorBignotto, Lpt_BR
dc.contributor.authorRocha, Jpt_BR
dc.contributor.authorSepodes, Bpt_BR
dc.contributor.authorEduardo-Figueira, Mpt_BR
dc.contributor.authorPinto, Rpt_BR
dc.contributor.authorChaud, Mpt_BR
dc.contributor.authorde Carvalho, Jpt_BR
dc.contributor.authorMoreno, Hpt_BR
dc.contributor.authorMota-Filipe, Hpt_BR
unicamp.author.emailhfilipe@ff.ul.ptpt_BR
unicamp.authorRocha, Joao Sepodes, Bruno Eduardo-Figueira, Maria Pinto, Rui Mota-Filipe, Helder Univ Lisbon, Fac Pharm, Unit Pharmacol & Pharmacotoxicol, IMEDUL Inflammat Team,Pharmacol Sci Grp, P-1649003 Lisbon, Portugalpt_BR
unicamp.authorBignotto, Leticia Moreno, Heitor, Jr. Univ Estadual Campinas, Fac Ciencias Med, Dept Farmacol, Sao Paulo, Brazilpt_BR
unicamp.authorChaud, Marco Univ Metodista Piracicaba, Fac Ciencias Saude, Sao Paulo, Brazilpt_BR
unicamp.authorde Carvalho, Joao Univ Estadual Campinas, Div Farmacol, Ctr Pluridisciplinar Pesquisas Quim Biol & Agr, Sao Paulo, Brazilpt_BR
dc.subjectLycopenept_BR
dc.subjectInflammationpt_BR
dc.subjectPaw oedemapt_BR
dc.subjectIschaemia-reperfusionpt_BR
dc.subjectLiverpt_BR
dc.subject.wosIschemia/reperfusion Injurypt_BR
dc.subject.wosAntioxidant Therapypt_BR
dc.subject.wosRadical Scavengerpt_BR
dc.subject.wosLiver-injurypt_BR
dc.subject.wosInflammationpt_BR
dc.subject.wosNetworkspt_BR
dc.subject.wosModelspt_BR
dc.subject.wosTempolpt_BR
dc.description.abstractThe regular intake of tomatoes or its products has been associated with a reduced risk of chronic diseases and these effects have been mainly attributed to lycopene. Here, we evaluated the anti-inflammatory properties of lycopene and its protective effects on organ injury in two experimental models of inflammation. In order to study the effects of lycopene in local inflammation, a carrageenan-induced paw oedema model in rats was performed. Lycopene was administered as an acute (1, 10, 25 or 50 mg/kg, intraperitoneally, 15 min before carrageenan injection) and chronic treatment (25 or 50 mg/kg per d, 14 d). Inflammation was assessed by the measurement of paw volume increase after 6 h. Lycopene significantly inhibited paw oedema formation at two doses (25 and 50 mg/kg) in both acute and repeated administration. The effect of lycopene on liver inflammation was evaluated in a liver ischaemia-reperfusion (I/R) model. Rats were subjected to 45 min of ischaemia of three-quarters of the liver followed by 2h of reperfusion. In this model, lycopene was administered daily at two doses (25 and 50mg/kg) during the 14d that preceded the experiments. Repeated administration of lycopene reduced liver injury induced by I/R, as demonstrated by the reduction of the increase in liver injury markers (aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase and gamma-glutamyl transferase) and attenuation of liver tissue lipoperoxidation was evidenced by a decrease in malondialdehyde production. The present results show that lycopene exhibited local anti-inflammatory activity and also attenuated liver injury induced by I/R. We speculate that lycopene administration might be useful in the pharmacological modulation of inflammatory events.pt
dc.description.noteo TEXTO COMPLETO DESTE ARTIGO, ESTARÁ DISPONÍVEL À PARTIR DE AGOSTO DE 2015.pt
dc.relation.ispartofBritish Journal Of Nutritionpt_BR
dc.relation.ispartofabbreviationBr. J. Nutr.pt_BR
dc.publisher.cityCambridgept_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherCambridge Univ Presspt_BR
dc.date.issued2009pt_BR
dc.date.monthofcirculation41821pt_BR
dc.identifier.citationBritish Journal Of Nutrition. Cambridge Univ Press, v. 102, n. 1, n. 126, n. 133, 2009.pt_BR
dc.language.isoenpt_BR
dc.description.volume102pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage126pt_BR
dc.description.lastpage133pt_BR
dc.rightsembargopt_BR
dc.rights.licensehttp://journals.cambridge.org/action/displaySpecialPage?pageId=4676pt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0007-1145pt_BR
dc.identifier.wosidWOS:000268311400014pt_BR
dc.identifier.doi10.1017/S0007114508137886pt_BR
dc.date.available2014-11-15T14:50:22Z
dc.date.available2015-11-26T16:11:43Z-
dc.date.accessioned2014-11-15T14:50:22Z
dc.date.accessioned2015-11-26T16:11:43Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T16:11:43Z (GMT). No. of bitstreams: 2 WOS000268311400014.pdf: 237542 bytes, checksum: 9bac3bff0a74512d8886c90354bfccd2 (MD5) WOS000268311400014.pdf.txt: 38743 bytes, checksum: e195a770673bedc4ad7d3fb6a2bbf7ce (MD5) Previous issue date: 2009en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77803pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/77803
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77803-
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